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Q5HLA3 (ALDA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase AldA

EC=1.2.1.3
Gene names
Name:aldA
Ordered Locus Names:SERP2084
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Putative aldehyde dehydrogenase AldA
PRO_0000056462

Regions

Nucleotide binding213 – 2197NAD By similarity

Sites

Active site2571 By similarity
Active site2911 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HLA3 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: DDCD2D2E0F2FDA7E

FASTA49754,247
        10         20         30         40         50         60 
MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK KDVDKAVQAA 

        70         80         90        100        110        120 
HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ NGKPYRETST IDVPQAANQF 

       130        140        150        160        170        180 
KYFASVLTTD EGSVNEIDQN TMSLVVNEPV GVVGAVVAWN FPILLASWKL GPALAAGNTV 

       190        200        210        220        230        240 
VIQPSSSTPL SLIELAKIFQ EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG 

       250        260        270        280        290        300 
YGVAQAGAER IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ 

       310        320        330        340        350        360 
SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE EDDKANILTG 

       370        380        390        400        410        420 
GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV VEKFDDEQEA IEIANDSEYG 

       430        440        450        460        470        480 
LAGGIFTTDI HRALNVAKAM RTGRIWINTY NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ 

       490 
QVKNIFIDTS NQTKGLY 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW52930.1.
RefSeqYP_189640.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HLA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP2084.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW52930; AAW52930; SERP2084.
GeneID3242375.
KEGGser:SERP2084.
PATRIC19615080. VBIStaEpi130894_2029.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00128.
OMADNGRDKG.
OrthoDBEOG6BS8QW.
ProtClustDBCLSK884447.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-2161-MONOMER.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDA_STAEQ
AccessionPrimary (citable) accession number: Q5HLA3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families