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Q5HLA3

- ALDA_STAEQ

UniProt

Q5HLA3 - ALDA_STAEQ

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Protein

Putative aldehyde dehydrogenase AldA

Gene

aldA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Active sitei291 – 2911By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2197NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2161-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase AldA (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:SERP2084
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Putative aldehyde dehydrogenase AldAPRO_0000056462Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2084.

Structurei

3D structure databases

ProteinModelPortaliQ5HLA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiMACWKMA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HLA3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK
60 70 80 90 100
KDVDKAVQAA HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ
110 120 130 140 150
NGKPYRETST IDVPQAANQF KYFASVLTTD EGSVNEIDQN TMSLVVNEPV
160 170 180 190 200
GVVGAVVAWN FPILLASWKL GPALAAGNTV VIQPSSSTPL SLIELAKIFQ
210 220 230 240 250
EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG YGVAQAGAER
260 270 280 290 300
IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ
310 320 330 340 350
SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE
360 370 380 390 400
EDDKANILTG GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV
410 420 430 440 450
VEKFDDEQEA IEIANDSEYG LAGGIFTTDI HRALNVAKAM RTGRIWINTY
460 470 480 490
NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ QVKNIFIDTS NQTKGLY
Length:497
Mass (Da):54,247
Last modified:February 15, 2005 - v1
Checksum:iDDCD2D2E0F2FDA7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW52930.1.
RefSeqiYP_189640.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52930; AAW52930; SERP2084.
GeneIDi3242375.
KEGGiser:SERP2084.
PATRICi19615080. VBIStaEpi130894_2029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW52930.1 .
RefSeqi YP_189640.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HLA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP2084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW52930 ; AAW52930 ; SERP2084 .
GeneIDi 3242375.
KEGGi ser:SERP2084.
PATRICi 19615080. VBIStaEpi130894_2029.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00128.
OMAi MACWKMA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-2161-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiALDA_STAEQ
AccessioniPrimary (citable) accession number: Q5HLA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3