Q5HL59 (ROCA_STAEQ) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 62.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 1-pyrroline-5-carboxylate dehydrogenase Short name=P5C dehydrogenase EC=1.5.1.12 | ||||
| Gene names |
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| Organism | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 176279 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus › ![]() |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP-Rule MF_00733 |
| Pathway | Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP-Rule MF_00733 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. RocA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | glutamate biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic processInferred from electronic annotation. Source: InterPro proline catabolic process to glutamateInferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 514 | 514 | 1-pyrroline-5-carboxylate dehydrogenase HAMAP-Rule MF_00733 | PRO_0000056521 | |||||
Sites | |||||||||
| Active site | 286 | 1 | By similarity | ||||||
| Active site | 320 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. Fraser C.M.J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000029 Genomic DNA. Translation: AAW53020.1. |
| RefSeq | YP_189684.1. NC_002976.3. |
3D structure databases | |
| ProteinModelPortal | Q5HL59. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 176279.SERP2128. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAW53020; AAW53020; SERP2128. |
| GeneID | 3241657. |
| KEGG | ser:SERP2128. |
| PATRIC | 19615164. VBIStaEpi130894_2071. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1012. |
| HOGENOM | HOG000271511. |
| KO | K00294. |
| OMA | SINPANT. |
| ProtClustDB | PRK03137. |
Enzyme and pathway databases | |
| BioCyc | SEPI176279:GJJB-2205-MONOMER. |
| UniPathway | UPA00261; UER00374. |
Family and domain databases | |
| Gene3D | 3.40.309.10. 1 hit. 3.40.605.10. 1 hit. |
| HAMAP | MF_00733. RocA. |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005932. Delta1-pyrroline-5-COlate_DH-2. [Graphical view] |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01237. D1pyr5carbox2. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ROCA_STAEQ | ||||||||
| Accession | Primary (citable) accession number: Q5HL59 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
