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Protein

Probable malate:quinone oxidoreductase 4

Gene

mqo4

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 4 (mqo4), Probable malate:quinone oxidoreductase 3 (mqo3), Probable malate:quinone oxidoreductase 2 (mqo2), Probable malate:quinone oxidoreductase 1 (mqo1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2245-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 4UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 4UniRule annotation
Malate dehydrogenase [quinone] 4UniRule annotation
Gene namesi
Name:mqo4UniRule annotation
Ordered Locus Names:SERP2168
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Probable malate:quinone oxidoreductase 4PRO_0000128756Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2168.

Structurei

3D structure databases

ProteinModelPortaliQ5HL19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiKTIAPDW.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HL19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE
60 70 80 90 100
RNNAGTGHAA LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS
110 120 130 140 150
GEIQNPKEFI NPLPHISFVR GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI
160 170 180 190 200
EEMRKWIPLM MKGREDKGYM AASKIDEGTD VNYGELTRKM AQNLKNSPNV
210 220 230 240 250
EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF IGAGGGAIPL
260 270 280 290 300
LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV
310 320 330 340 350
PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS
360 370 380 390 400
AVKNLPLIKY SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI
410 420 430 440 450
KDTEENGKGF IQFGTEVVNS EDHSVIALLG ESPGASTSVS VALEVLEKNF
460 470 480 490
PEYAKNWEPK IKKMIPSYGE SLIDDVQLMR KIRKQTSKDL ELGFYDKAK
Length:499
Mass (Da):56,353
Last modified:February 15, 2005 - v1
Checksum:iBB079D034F454DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52954.1.
RefSeqiWP_002477163.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52954; AAW52954; SERP2168.
KEGGiser:SERP2168.
PATRICi19615244. VBIStaEpi130894_2111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52954.1.
RefSeqiWP_002477163.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HL19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP2168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW52954; AAW52954; SERP2168.
KEGGiser:SERP2168.
PATRICi19615244. VBIStaEpi130894_2111.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiKTIAPDW.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciSEPI176279:GJJB-2245-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO4_STAEQ
AccessioniPrimary (citable) accession number: Q5HL19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.