Q5HL19 (MQO4_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase 4
EC=1.1.5.4

Alternative name(s):
MQO 4
Malate dehydrogenase [quinone] 4

Gene names

Name:	mqo4
Ordered Locus Names:	SERP2168

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Probable malate:quinone oxidoreductase 4 HAMAP MF_00212		PRO_0000128756

Sequences

	Sequence		Length	Mass (Da)
	Q5HL19 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: BB079D034F454DE4	FASTA	499	56,353
	10 20 30 40 50 60 MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE RNNAGTGHAA 70 80 90 100 110 120 LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GEIQNPKEFI NPLPHISFVR 130 140 150 160 170 180 GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI EEMRKWIPLM MKGREDKGYM AASKIDEGTD 190 200 210 220 230 240 VNYGELTRKM AQNLKNSPNV EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF 250 260 270 280 290 300 IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV 310 320 330 340 350 360 PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS AVKNLPLIKY 370 380 390 400 410 420 SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI KDTEENGKGF IQFGTEVVNS 430 440 450 460 470 480 EDHSVIALLG ESPGASTSVS VALEVLEKNF PEYAKNWEPK IKKMIPSYGE SLIDDVQLMR 490 KIRKQTSKDL ELGFYDKAK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW52954.1.
RefSeq	YP_189724.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HL19.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HL19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000042748; EBSTAP00000041291; EBSTAG00000042746.
GeneID	3240910.
GenomeReviews	Gene locus SERP2168 in contig CP000029_GR.
KEGG	ser:SERP2168.
NMPDR	fig|176279.3.peg.1576.
PATRIC	19615244. VBIStaEpi130894_2111.
TIGR	SERP2168.
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000024300.
HOGENOM	HBG289663.
OMA	NSEDHSV.
ProtClustDB	PRK13339.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP2168-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO4_STAEQ

Accession

Primary (citable) accession number: Q5HL19

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program