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Q5HL11

- BETA_STAEQ

UniProt

Q5HL11 - BETA_STAEQ

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, SERP2176
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei477 – 4771 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 3830FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2253-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:SERP2176
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_0000205602Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2176.

Structurei

3D structure databases

ProteinModelPortaliQ5HL11.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HL11-1 [UniParc]FASTAAdd to Basket

« Hide

MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI    50
QMPAALMFPS GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY 100
QRGNPMDYEG WAEPEGMDTW DFAHCLPYFK KLETTYGAAP YDKVRGHDGP 150
IKLKRGPATN PLFKSFFNAG VEAGYHKTAD VNGYRQEGFG PFDSQVHHGR 200
RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT GVTFKKNGKE 250
HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF 300
EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG 350
GFVRSNDDVD YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS 400
LKIKSKDPFE KPSIVFNYLS TKEDEREWIE AIRVARNILK QKAMDPFNGG 450
EISPGPQVQT DEEILDWVRK DGETALHPSC SAKMGPASDP MAVVDPLTMK 500
VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG RKPLEPQYVD 550
YYKHGIDDEK AGAMEDDPFY QY 572
Length:572
Mass (Da):64,275
Last modified:February 15, 2005 - v1
Checksum:iCF4DA94BDCEF6BF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW52969.1.
RefSeqiWP_010959300.1. NC_002976.3.
YP_189732.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52969; AAW52969; SERP2176.
GeneIDi3242368.
KEGGiser:SERP2176.
PATRICi19615258. VBIStaEpi130894_2118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW52969.1 .
RefSeqi WP_010959300.1. NC_002976.3.
YP_189732.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HL11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP2176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW52969 ; AAW52969 ; SERP2176 .
GeneIDi 3242368.
KEGGi ser:SERP2176.
PATRICi 19615258. VBIStaEpi130894_2118.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SEPI176279:GJJB-2253-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiBETA_STAEQ
AccessioniPrimary (citable) accession number: Q5HL11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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