Reviewed, UniProtKB/Swiss-Prot Q5HL11 (BETA_STAEQ)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	SERP2176

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Choline dehydrogenase HAMAP MF_00750		PRO_0000205602
Regions
	Nucleotide binding	9 – 38	30	FAD Probable
Sites
	Active site	477	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HL11-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: CF4DA94BDCEF6BF4	FASTA	572	64,275
	10 20 30 40 50 60 MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI QMPAALMFPS 70 80 90 100 110 120 GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY QRGNPMDYEG WAEPEGMDTW 130 140 150 160 170 180 DFAHCLPYFK KLETTYGAAP YDKVRGHDGP IKLKRGPATN PLFKSFFNAG VEAGYHKTAD 190 200 210 220 230 240 VNGYRQEGFG PFDSQVHHGR RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT 250 260 270 280 290 300 GVTFKKNGKE HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF 310 320 330 340 350 360 EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG GFVRSNDDVD 370 380 390 400 410 420 YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS LKIKSKDPFE KPSIVFNYLS 430 440 450 460 470 480 TKEDEREWIE AIRVARNILK QKAMDPFNGG EISPGPQVQT DEEILDWVRK DGETALHPSC 490 500 510 520 530 540 SAKMGPASDP MAVVDPLTMK VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG 550 560 570 RKPLEPQYVD YYKHGIDDEK AGAMEDDPFY QY

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000029 Genomic DNA. Translation: AAW52969.1.
RefSeq	YP_189732.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3242368.
GenomeReviews	Gene locus SERP2176 in contig CP000029_GR.
KEGG	ser:SERP2176.
NMPDR	fig|176279.3.peg.1584.
TIGR	SERP2176.
Phylogenomic databases
HOGENOM	Q5HL11.
OMA	Q5HL11. PNLQYHF.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP2176-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_STAEQ

Accession

Primary (citable) accession number: Q5HL11

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)