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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei477Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 38FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSEPI176279:G1G46-2234-MONOMER
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:SERP2176
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056021 – 572Oxygen-dependent choline dehydrogenaseAdd BLAST572

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2176

Structurei

3D structure databases

ProteinModelPortaliQ5HL11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HL11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI
60 70 80 90 100
QMPAALMFPS GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY
110 120 130 140 150
QRGNPMDYEG WAEPEGMDTW DFAHCLPYFK KLETTYGAAP YDKVRGHDGP
160 170 180 190 200
IKLKRGPATN PLFKSFFNAG VEAGYHKTAD VNGYRQEGFG PFDSQVHHGR
210 220 230 240 250
RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT GVTFKKNGKE
260 270 280 290 300
HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF
310 320 330 340 350
EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG
360 370 380 390 400
GFVRSNDDVD YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS
410 420 430 440 450
LKIKSKDPFE KPSIVFNYLS TKEDEREWIE AIRVARNILK QKAMDPFNGG
460 470 480 490 500
EISPGPQVQT DEEILDWVRK DGETALHPSC SAKMGPASDP MAVVDPLTMK
510 520 530 540 550
VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG RKPLEPQYVD
560 570
YYKHGIDDEK AGAMEDDPFY QY
Length:572
Mass (Da):64,275
Last modified:February 15, 2005 - v1
Checksum:iCF4DA94BDCEF6BF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW52969.1
RefSeqiWP_010959300.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW52969; AAW52969; SERP2176
KEGGiser:SERP2176

Similar proteinsi

Entry informationi

Entry nameiBETA_STAEQ
AccessioniPrimary (citable) accession number: Q5HL11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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