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Q5HL11 (BETA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:SERP2176
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205602

Regions

Nucleotide binding9 – 3830FAD By similarity

Sites

Active site4771 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HL11 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: CF4DA94BDCEF6BF4

FASTA57264,275
        10         20         30         40         50         60 
MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI QMPAALMFPS 

        70         80         90        100        110        120 
GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY QRGNPMDYEG WAEPEGMDTW 

       130        140        150        160        170        180 
DFAHCLPYFK KLETTYGAAP YDKVRGHDGP IKLKRGPATN PLFKSFFNAG VEAGYHKTAD 

       190        200        210        220        230        240 
VNGYRQEGFG PFDSQVHHGR RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT 

       250        260        270        280        290        300 
GVTFKKNGKE HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF 

       310        320        330        340        350        360 
EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG GFVRSNDDVD 

       370        380        390        400        410        420 
YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS LKIKSKDPFE KPSIVFNYLS 

       430        440        450        460        470        480 
TKEDEREWIE AIRVARNILK QKAMDPFNGG EISPGPQVQT DEEILDWVRK DGETALHPSC 

       490        500        510        520        530        540 
SAKMGPASDP MAVVDPLTMK VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG 

       550        560        570 
RKPLEPQYVD YYKHGIDDEK AGAMEDDPFY QY 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW52969.1.
RefSeqYP_189732.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HL11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP2176.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW52969; AAW52969; SERP2176.
GeneID3242368.
KEGGser:SERP2176.
PATRIC19615258. VBIStaEpi130894_2118.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-2253-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STAEQ
AccessionPrimary (citable) accession number: Q5HL11
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways