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Protein
Submitted name:

Transcriptional regulator, MarR family

Gene

SERP2196

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2273-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator, MarR familyImported
Gene namesi
Ordered Locus Names:SERP2196Imported
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)Imported
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2196.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HBLX-ray2.50A/B/C/D1-146[»]
ProteinModelPortaliQ5HKZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH marR-type DNA-binding domains.UniRule annotation

Phylogenomic databases

eggNOGiCOG1846.
HOGENOMiHOG000221448.
OMAiGCFENAD.
OrthoDBiEOG6SR975.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEQMRLAN QLCFSAYNVS RLFAQFYEKK LKQFGITYSQ YLVLLTLWEE
60 70 80 90 100
NPQTLNSIGR HLDLSSNTLT PLLKRLEQSG WVKRERQQSD KRQLIITLTD
110 120 130 140
NGQQQQEAVF EAISSCLPQE FDTTEYDETK YVFEELEQTL KHLIEK
Length:146
Mass (Da):17,302
Last modified:February 15, 2005 - v1
Checksum:i6440549D2E5EC4A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53014.1.
RefSeqiYP_189752.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53014; AAW53014; SERP2196.
GeneIDi3241553.
KEGGiser:SERP2196.
PATRICi19615296. VBIStaEpi130894_2137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53014.1.
RefSeqiYP_189752.1. NC_002976.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HBLX-ray2.50A/B/C/D1-146[»]
ProteinModelPortaliQ5HKZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP2196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW53014; AAW53014; SERP2196.
GeneIDi3241553.
KEGGiser:SERP2196.
PATRICi19615296. VBIStaEpi130894_2137.

Phylogenomic databases

eggNOGiCOG1846.
HOGENOMiHOG000221448.
OMAiGCFENAD.
OrthoDBiEOG6SR975.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2273-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62AImported.
  2. "Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis."
    Liu X., Sun X., Wu Y., Xie C., Zhang W., Wang D., Chen X., Qu D., Gan J., Chen H., Jiang H., Lan L., Yang C.G.
    J. Biol. Chem. 288:3739-3752(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).

Entry informationi

Entry nameiQ5HKZ1_STAEQ
AccessioniPrimary (citable) accession number: Q5HKZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.