ID   ARCR_STAEQ              Reviewed;         228 AA.
AC   Q5HKU6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SERP2246;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CP000029; AAW53105.1; -; Genomic_DNA.
DR   RefSeq; WP_002486086.1; NC_002976.3.
DR   AlphaFoldDB; Q5HKU6; -.
DR   SMR; Q5HKU6; -.
DR   STRING; 176279.SERP2246; -.
DR   KEGG; ser:SERP2246; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR24567; CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR24567:SF82; HTH-TYPE TRANSCRIPTIONAL REGULATOR ARCR; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..228
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349419"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         22..141
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   228 AA;  26896 MW;  07371F0A85C1D475 CRC64;
     MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY YSSDETTHIY
     LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP NEMCTALTDC EMIGIPRDLI
     EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM ALTSKLAKER VTKILRYLCQ TVGYDHDEFY
     EIKHFMTIQL LSDMAGISRE TTSHIINELK EEKILFKNSK NWLVSKDL
//