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Q5HKU6

- ARCR_STAEQ

UniProt

Q5HKU6 - ARCR_STAEQ

Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 141120cNMPAdd
    BLAST
    DNA bindingi188 – 20720H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-2323-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator ArcR
    Gene namesi
    Name:arcR
    Ordered Locus Names:SERP2246
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228HTH-type transcriptional regulator ArcRPRO_0000349419Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176279.SERP2246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HKU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 22874HTH crp-typeAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000022896.
    OMAiERVNQNG.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5HKU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY    50
    YSSDETTHIY LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP 100
    NEMCTALTDC EMIGIPRDLI EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM 150
    ALTSKLAKER VTKILRYLCQ TVGYDHDEFY EIKHFMTIQL LSDMAGISRE 200
    TTSHIINELK EEKILFKNSK NWLVSKDL 228
    Length:228
    Mass (Da):26,896
    Last modified:February 15, 2005 - v1
    Checksum:i07371F0A85C1D475
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53105.1.
    RefSeqiYP_189797.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW53105; AAW53105; SERP2246.
    GeneIDi3240478.
    KEGGiser:SERP2246.
    PATRICi19615391. VBIStaEpi130894_2184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53105.1 .
    RefSeqi YP_189797.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HKU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP2246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW53105 ; AAW53105 ; SERP2246 .
    GeneIDi 3240478.
    KEGGi ser:SERP2246.
    PATRICi 19615391. VBIStaEpi130894_2184.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000022896.
    OMAi ERVNQNG.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-2323-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiARCR_STAEQ
    AccessioniPrimary (citable) accession number: Q5HKU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3