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Q5HKP6 (LIP_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipase
EC=3.1.1.3
Alternative name(s):
Glycerol ester hydrolase
Gene names
Name:lip
Ordered Locus Names:SERP2297
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Propeptide36 – 302267Removed in mature form By similarity
PRO_0000045196
Chain303 – 688386Lipase
PRO_0000045197

Sites

Active site4181Charge relay system By similarity
Active site6481Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HKP6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 18EE607D54B0908F

FASTA68877,410
        10         20         30         40         50         60 
MKTRQNKYSI RKFSVGASSI LIAALLFMGG GSAQAAEQQQ DKGTVENSTT QSIGDENEKL 

        70         80         90        100        110        120 
SEQQSTQNKN VNEKSNVDSI TENESLHNET PKNEDLIQQQ KDSQNDNKSE SVVEQNKENE 

       130        140        150        160        170        180 
AFVKKHSEEK PQQEQVELEK HASENNQTLH SKAAQSNEDV KTKPSQLDNT TAQQEDSQKE 

       190        200        210        220        230        240 
NLSKQDTQSS KTTDLLRATG QNQSKDSQST EEVNKEVKND TQQVTAKNDD DKVETFNLNS 

       250        260        270        280        290        300 
KEEPLKVDKQ ANPTTDKDKS SKNDKGSHDG LANLESNAVA TTNKQSKQQV SEKNEDQTNK 

       310        320        330        340        350        360 
SAKQKQYKNN DPIILVHGFN GFTDDINPSV LTHYWGGDKM NIRQDLEENG YEAYEASISA 

       370        380        390        400        410        420 
FGSNYDRAVE LYYYIKGGRV DYGAAHAAKY GHERYGKTYE GVYKDWKPGQ KIHLVGHSMG 

       430        440        450        460        470        480 
GQTIRQLEEL LRHGNPEEVE YQKQHGGEIS PLFQGGHDNM VSSITTLGTP HNGTHASDLL 

       490        500        510        520        530        540 
GNEAIVRQLA YDVGKMYGNK DSRVDFGLEH WGLKQKPNES YIQYVKRVQN SKLWKSKDSG 

       550        560        570        580        590        600 
LHDLTRDGAT DLNRKTSLNP NIVYKTYTGE STHKTLAGKQ KADLNMFLPF TITGNLIGKA 

       610        620        630        640        650        660 
KEKEWRENDG LVSVISSQHP FNQKYVEATD KNQKGVWQVT PTKHDWDHVD FVGQDSTDTK 

       670        680 
RTRDELQQFW HGLADDLVQS EQLTSTNK

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000029 Genomic DNA. Translation: AAW53186.1.
RefSeqYP_189847.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HKP6.
SMRQ5HKP6. Positions 307-686.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HKP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000043001; EBSTAP00000041544; EBSTAG00000042999.
GeneID3242233.
GenomeReviewsGene locus SERP2297 in contig CP000029_GR.
KEGGser:SERP2297.
NMPDRfig|176279.3.peg.1886.
PATRIC19615489. VBIStaEpi130894_2232.
TIGRSERP2297.

Phylogenomic databases

eggNOGCOG1075.
GeneTreeEBGT00050000023709.
HOGENOMHBG694146.
OMAYTGESTH.
ProtClustDBCLSK2752181.

Enzyme and pathway databases

BioCycSEPI176279:SERP2297-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
[Graphical view]
KOK01046.
PfamPF04650. YSIRK_signal. 1 hit.
[Graphical view]
TIGRFAMsTIGR01168. YSIRK_signal. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIP_STAEQ
AccessionPrimary (citable) accession number: Q5HKP6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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