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Q5HKN8 (HISX_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:SERP2305
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135856

Sites

Active site3131Proton acceptor By similarity
Active site3141Proton acceptor By similarity
Metal binding2451Zinc By similarity
Metal binding2481Zinc By similarity
Metal binding3471Zinc By similarity
Metal binding4061Zinc By similarity
Binding site1161NAD By similarity
Binding site1771NAD By similarity
Binding site2001NAD By similarity
Binding site2231Substrate By similarity
Binding site2451Substrate By similarity
Binding site2481Substrate By similarity
Binding site3141Substrate By similarity
Binding site3471Substrate By similarity
Binding site4011Substrate By similarity
Binding site4061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HKN8 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: F562E9E88AFA6E43

FASTA41446,427
        10         20         30         40         50         60 
MLSAQQFLKE FNNVESLDES LYEIVSQICE EVKLQGDKAL KNYNLQFDQV ETEKLELEQS 

        70         80         90        100        110        120 
QLKNAYDMLD NETRDALEQS YQRIKVYQEN IKVKQESSQQ TECYERYHPI ERVGIYVPGG 

       130        140        150        160        170        180 
KASYPSTVLM TATLAQVAGV NEITVVTPPQ NSGICQEVLA ACYITGVHHV YQVGGAQSIA 

       190        200        210        220        230        240 
ALTYGTETIK KVDKIVGPGN QYVAYAKKFV FGQVGIDQIA GPTEIALIID ESADLDAIAY 

       250        260        270        280        290        300 
DVFAQAEHDE MACTYVISEN EKVLNQLNTI IQEKLQYVER QDIISQSIAN HHYLILAQDT 

       310        320        330        340        350        360 
EEACLIMNTI APEHASIQTR APEMYIDKVK YVGALFLGHF SPEVIGDYVA GPSHVLPTNQ 

       370        380        390        400        410 
TARFTNGLSV NDFMTRHSVI HLSQKTFNEV AESAEHIAHI ESLFNHEKSI HVRR 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW53202.1.
RefSeqYP_189855.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HKN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP2305.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW53202; AAW53202; SERP2305.
GeneID3240932.
KEGGser:SERP2305.
PATRIC19615503. VBIStaEpi130894_2239.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK13770.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-2383-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_STAEQ
AccessionPrimary (citable) accession number: Q5HKN8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways