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Q5HKE8

- Q5HKE8_STAEQ

UniProt

Q5HKE8 - Q5HKE8_STAEQ

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Protein
Submitted name:

Accumulation associated protein

Gene

aap

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2035 – 20351Zinc
Metal bindingi2037 – 20371ZincImported
Metal bindingi2091 – 20911Zinc; via pros nitrogenImported
Metal bindingi2165 – 21651ZincImported
Metal bindingi2219 – 22191ZincImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, ZincImported

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2476-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Accumulation associated proteinImported
Gene namesi
Name:aapImported
Ordered Locus Names:SERP2398Imported
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)Imported
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

Secretedcell wall SAAS annotation; Peptidoglycan-anchor SAAS annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wallUniRule annotation, Secreted

PTM / Processingi

Keywords - PTMi

Peptidoglycan-anchorUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2398.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FUMX-ray2.40A2017-2223[»]
4FUNX-ray2.31A2017-2223[»]
4FUOX-ray1.97A2017-2223[»]
4FUPX-ray2.51A/B2017-2223[»]
ProteinModelPortaliQ5HKE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG12793.
KOiK14195.
OMAiQSEPTKA.

Family and domain databases

InterProiIPR011098. G5_dom.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF07501. G5. 13 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS51109. G5. 13 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HKE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKRRQGPIN KKVDFLPNKL NKYSIRKFTV GTASILLGST LIFGSSSHEA
60 70 80 90 100
KAAEEKQVDP ITQANQNDSS ERSLENTNQP TVNNEAPQMS STLQAEEGSN
110 120 130 140 150
AEAPQSEPTK AEEGGNAEAA QSEPTKAEEG GNAEAPQSEP TKAEEGGNAE
160 170 180 190 200
AAQSEPTKTE EGSNVKAAQS EPTKAEEGSN AEAPQSEPTK TEEGSNAKAA
210 220 230 240 250
QSEPTKAEEG GNAEAAQSEP TKTEEGSNAE APQSEPTKAE EGGNAEAPQS
260 270 280 290 300
EPTKTEEGGN AEAPNVPTIK ANSDNDTQTQ FSEAPTRNDL ARKEDIPAVS
310 320 330 340 350
KNEELQSSQP NTDSKIEPTT SEPVNLNYSS PFMSLLSMPA DSSSNNTKNT
360 370 380 390 400
IDIPPTTVKG RDNYDFYGRV DIESNPTDLN ATNLTRYNYG QPPGTTTAGA
410 420 430 440 450
VQFKNQVSFD KDFDFNIRVA NNRQSNTTGA DGWGFMFSKK DGDDFLKNGG
460 470 480 490 500
ILREKGTPSA AGFRIDTGYY NNDPLDKIQK QAGQGYRGYG TFVKNDSQGN
510 520 530 540 550
TSKVGSGTPS TDFLNYADNT TNDLDGKFHG QKLNNVNLKY NASNQTFTAT
560 570 580 590 600
YAGKTWTATL SELGLSPTDS YNFLVTSSQY GNGNSGTYAS GVMRADLDGA
610 620 630 640 650
TLTYTPKAVD GDPIISTKEI PFNKKREFDP NLAPGTEKVV QKGEPGIETT
660 670 680 690 700
TTPTYVNPNT GEKVGEGEPT EKITKQPVDE IVHYGGEEIK PGHKDEFDPN
710 720 730 740 750
APKGSQTTQP GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD PITSTEEIPF
760 770 780 790 800
DKKREFNPDL KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK
810 820 830 840 850
ITKQPVDEIT EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE
860 870 880 890 900
VVTPPVDDVT KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE
910 920 930 940 950
PGTKTITTPT TKNPLTGEKV GEGEPTEKVT KQPVDEITEY GGEEIKPGHK
960 970 980 990 1000
DEFDPNAPKG SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS
1010 1020 1030 1040 1050
TEEIPFDKKR EFDPNLAPGT EKVVQKGEPG TKTITTPTTK NPLTGEKVGE
1060 1070 1080 1090 1100
GEPTEKVTKQ PVDEIVHYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK
1110 1120 1130 1140 1150
NPDTGEVVTP PVDDVTKYGP VDGDPITSTE EIPFDKKREF DPNLAPGTEK
1160 1170 1180 1190 1200
VVQKGEPGTK TITTPTTKNP LTGEKVGEGE PTEKVTKQPV DEIVHYGGEE
1210 1220 1230 1240 1250
IKPGHKDEFD PNAPKGSQED VPGKPGVKNP DTGEVVTPPV DDVTKYGPVD
1260 1270 1280 1290 1300
GDPITSTEEI PFDKKREFNP DLKPGEERVK QKGEPGTKTI TTPTTKNPLT
1310 1320 1330 1340 1350
GEKVGEGEPT EKITKQPVDE ITEYGGEEIK PGHKDEFDPN APKGSQTTQP
1360 1370 1380 1390 1400
GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD PITSTEEIPF DKKREFNPDL
1410 1420 1430 1440 1450
KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIT
1460 1470 1480 1490 1500
EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE VVTPPVDDVT
1510 1520 1530 1540 1550
KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE PGTKTITTPT
1560 1570 1580 1590 1600
TKNPLTGEKV GEGEPTEKIT KQPVDEITEY GGEEIKPGHK DEFDPNAPKG
1610 1620 1630 1640 1650
SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS TEEIPFDKKR
1660 1670 1680 1690 1700
EFDPNLAPGT EKVVQKGEPG TKTITTPTTK NPLTGEKVGE GEPTEKITKQ
1710 1720 1730 1740 1750
PVDEITEYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK NPDTGEVVTP
1760 1770 1780 1790 1800
PVDDVTKYGP VDGDPITSTE EIPFDKKREF DPNLAPGTEK VVQKGEPGTK
1810 1820 1830 1840 1850
TITTPTTKNP LTGEKVGEGE PTEKITKQPV DEIVHYGGEE IKTGHKDEFD
1860 1870 1880 1890 1900
PNAPKGSQTT QPGKPGVKNP DTGEVVTPPV DDVTKYGPVD GDPITSTEEI
1910 1920 1930 1940 1950
PFDKKREFDP NLAPGTEKVV QKGEPGTKTI TTPTTKNPLT GEKVGEGEPT
1960 1970 1980 1990 2000
EKITKQPVDE IVHYGGEEIK PGHKDEFDPN APKGSQEDVP GKPGVKNPDT
2010 2020 2030 2040 2050
GEVVTPPVDD VTKYGPVDGD SITSTEEIPF DKKREFDPNL APGTEKVVQK
2060 2070 2080 2090 2100
GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIV HYGGEQIPQG
2110 2120 2130 2140 2150
HKDEFDPNAP VDSKTEVPGK PGVKNPDTGE VVTPPVDDVT KYGPVDGDSI
2160 2170 2180 2190 2200
TSTEEIPFDK KREFDPNLAP GTEKVVQKGE PGTKTITTPT TKNPLTGEKV
2210 2220 2230 2240 2250
GEGKSTEKVT KQPVDEIVEY GPTKAEPGKP AEPGKPAEPG KPAEPGTPAE
2260 2270 2280 2290 2300
PGKPAEPGTP AEPGKPAEPG KPAEPGKPAE PGKPAEPGTP AEPGTPAEPG
2310 2320 2330 2340 2350
KPAEPGTPAE PGKPAEPGTP AEPGKPAESG KPVEPGTPAQ SGAPEQPNRS
2360 2370 2380 2390
MHSTDNKNQL PDTGENRQAN EGTLVGSLLA IVGSLFIFGR RKKGNEK
Length:2,397
Mass (Da):255,612
Last modified:February 15, 2005 - v1
Checksum:i577FB0A4E5DDE15E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53239.1.
RefSeqiYP_189945.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53239; AAW53239; SERP2398.
GeneIDi3242404.
KEGGiser:SERP2398.
PATRICi19615683. VBIStaEpi130894_2329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53239.1 .
RefSeqi YP_189945.1. NC_002976.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FUM X-ray 2.40 A 2017-2223 [» ]
4FUN X-ray 2.31 A 2017-2223 [» ]
4FUO X-ray 1.97 A 2017-2223 [» ]
4FUP X-ray 2.51 A/B 2017-2223 [» ]
ProteinModelPortali Q5HKE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP2398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW53239 ; AAW53239 ; SERP2398 .
GeneIDi 3242404.
KEGGi ser:SERP2398.
PATRICi 19615683. VBIStaEpi130894_2329.

Phylogenomic databases

eggNOGi NOG12793.
KOi K14195.
OMAi QSEPTKA.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-2476-MONOMER.

Family and domain databases

InterProi IPR011098. G5_dom.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF07501. G5. 13 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS51109. G5. 13 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62AImported.
  2. "Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms."
    Conrady D.G., Wilson J.J., Herr A.B.
    Proc. Natl. Acad. Sci. U.S.A. 110:E202-E211(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2017-2223 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ5HKE8_STAEQ
AccessioniPrimary (citable) accession number: Q5HKE8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3