Q5HKE8 (Q5HKE8_STAEQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Accumulation associated protein EMBL AAW53239.1

Gene names

Name:	aap EMBL AAW53239.1
Ordered Locus Names:	SERP2398 EMBL AAW53239.1

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP] EMBL AAW53239.1

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	2397 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Secreted › cell wall; Peptidoglycan-anchor By similarity SAAS SAAS005877.

Ontologies

Keywords
Cellular component	Cell wall RuleBase RU000373 Secreted
PTM	Peptidoglycan-anchor RuleBase RU000373
Technical term	3D-structure PDB 4FUM PDB 4FUN PDB 4FUO PDB 4FUP Complete proteome
Gene Ontology (GO)
Cellular_component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5HKE8 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 577FB0A4E5DDE15E	FASTA	2,397	255,612
	10 20 30 40 50 60 MGKRRQGPIN KKVDFLPNKL NKYSIRKFTV GTASILLGST LIFGSSSHEA KAAEEKQVDP 70 80 90 100 110 120 ITQANQNDSS ERSLENTNQP TVNNEAPQMS STLQAEEGSN AEAPQSEPTK AEEGGNAEAA 130 140 150 160 170 180 QSEPTKAEEG GNAEAPQSEP TKAEEGGNAE AAQSEPTKTE EGSNVKAAQS EPTKAEEGSN 190 200 210 220 230 240 AEAPQSEPTK TEEGSNAKAA QSEPTKAEEG GNAEAAQSEP TKTEEGSNAE APQSEPTKAE 250 260 270 280 290 300 EGGNAEAPQS EPTKTEEGGN AEAPNVPTIK ANSDNDTQTQ FSEAPTRNDL ARKEDIPAVS 310 320 330 340 350 360 KNEELQSSQP NTDSKIEPTT SEPVNLNYSS PFMSLLSMPA DSSSNNTKNT IDIPPTTVKG 370 380 390 400 410 420 RDNYDFYGRV DIESNPTDLN ATNLTRYNYG QPPGTTTAGA VQFKNQVSFD KDFDFNIRVA 430 440 450 460 470 480 NNRQSNTTGA DGWGFMFSKK DGDDFLKNGG ILREKGTPSA AGFRIDTGYY NNDPLDKIQK 490 500 510 520 530 540 QAGQGYRGYG TFVKNDSQGN TSKVGSGTPS TDFLNYADNT TNDLDGKFHG QKLNNVNLKY 550 560 570 580 590 600 NASNQTFTAT YAGKTWTATL SELGLSPTDS YNFLVTSSQY GNGNSGTYAS GVMRADLDGA 610 620 630 640 650 660 TLTYTPKAVD GDPIISTKEI PFNKKREFDP NLAPGTEKVV QKGEPGIETT TTPTYVNPNT 670 680 690 700 710 720 GEKVGEGEPT EKITKQPVDE IVHYGGEEIK PGHKDEFDPN APKGSQTTQP GKPGVKNPDT 730 740 750 760 770 780 GEVVTPPVDD VTKYGPVDGD PITSTEEIPF DKKREFNPDL KPGEERVKQK GEPGTKTITT 790 800 810 820 830 840 PTTKNPLTGE KVGEGEPTEK ITKQPVDEIT EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK 850 860 870 880 890 900 PGVKNPDTGE VVTPPVDDVT KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE 910 920 930 940 950 960 PGTKTITTPT TKNPLTGEKV GEGEPTEKVT KQPVDEITEY GGEEIKPGHK DEFDPNAPKG 970 980 990 1000 1010 1020 SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS TEEIPFDKKR EFDPNLAPGT 1030 1040 1050 1060 1070 1080 EKVVQKGEPG TKTITTPTTK NPLTGEKVGE GEPTEKVTKQ PVDEIVHYGG EEIKPGHKDE 1090 1100 1110 1120 1130 1140 FDPNAPKGSQ EDVPGKPGVK NPDTGEVVTP PVDDVTKYGP VDGDPITSTE EIPFDKKREF 1150 1160 1170 1180 1190 1200 DPNLAPGTEK VVQKGEPGTK TITTPTTKNP LTGEKVGEGE PTEKVTKQPV DEIVHYGGEE 1210 1220 1230 1240 1250 1260 IKPGHKDEFD PNAPKGSQED VPGKPGVKNP DTGEVVTPPV DDVTKYGPVD GDPITSTEEI 1270 1280 1290 1300 1310 1320 PFDKKREFNP DLKPGEERVK QKGEPGTKTI TTPTTKNPLT GEKVGEGEPT EKITKQPVDE 1330 1340 1350 1360 1370 1380 ITEYGGEEIK PGHKDEFDPN APKGSQTTQP GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD 1390 1400 1410 1420 1430 1440 PITSTEEIPF DKKREFNPDL KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK 1450 1460 1470 1480 1490 1500 ITKQPVDEIT EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE VVTPPVDDVT 1510 1520 1530 1540 1550 1560 KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE PGTKTITTPT TKNPLTGEKV 1570 1580 1590 1600 1610 1620 GEGEPTEKIT KQPVDEITEY GGEEIKPGHK DEFDPNAPKG SQEDVPGKPG VKNPDTGEVV 1630 1640 1650 1660 1670 1680 TPPVDDVTKY GPVDGDPITS TEEIPFDKKR EFDPNLAPGT EKVVQKGEPG TKTITTPTTK 1690 1700 1710 1720 1730 1740 NPLTGEKVGE GEPTEKITKQ PVDEITEYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK 1750 1760 1770 1780 1790 1800 NPDTGEVVTP PVDDVTKYGP VDGDPITSTE EIPFDKKREF DPNLAPGTEK VVQKGEPGTK 1810 1820 1830 1840 1850 1860 TITTPTTKNP LTGEKVGEGE PTEKITKQPV DEIVHYGGEE IKTGHKDEFD PNAPKGSQTT 1870 1880 1890 1900 1910 1920 QPGKPGVKNP DTGEVVTPPV DDVTKYGPVD GDPITSTEEI PFDKKREFDP NLAPGTEKVV 1930 1940 1950 1960 1970 1980 QKGEPGTKTI TTPTTKNPLT GEKVGEGEPT EKITKQPVDE IVHYGGEEIK PGHKDEFDPN 1990 2000 2010 2020 2030 2040 APKGSQEDVP GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD SITSTEEIPF DKKREFDPNL 2050 2060 2070 2080 2090 2100 APGTEKVVQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIV HYGGEQIPQG 2110 2120 2130 2140 2150 2160 HKDEFDPNAP VDSKTEVPGK PGVKNPDTGE VVTPPVDDVT KYGPVDGDSI TSTEEIPFDK 2170 2180 2190 2200 2210 2220 KREFDPNLAP GTEKVVQKGE PGTKTITTPT TKNPLTGEKV GEGKSTEKVT KQPVDEIVEY 2230 2240 2250 2260 2270 2280 GPTKAEPGKP AEPGKPAEPG KPAEPGTPAE PGKPAEPGTP AEPGKPAEPG KPAEPGKPAE 2290 2300 2310 2320 2330 2340 PGKPAEPGTP AEPGTPAEPG KPAEPGTPAE PGKPAEPGTP AEPGKPAESG KPVEPGTPAQ 2350 2360 2370 2380 2390 SGAPEQPNRS MHSTDNKNQL PDTGENRQAN EGTLVGSLLA IVGSLFIFGR RKKGNEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J., Khouri H. , Utterback T., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.
[2]	"Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms." Conrady D.G., Wilson J.J., Herr A.B. Proc. Natl. Acad. Sci. U.S.A. 110:E202-E211(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2017-2223.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000029 Genomic DNA. Translation: AAW53239.1.

RefSeq

YP_189945.1. NC_002976.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FUM	X-ray	2.40	A	2017-2223	[»]
4FUN	X-ray	2.31	A	2017-2223	[»]
4FUO	X-ray	1.97	A	2017-2223	[»]
4FUP	X-ray	2.51	A/B	2017-2223	[»]

ProteinModelPortal

Q5HKE8.

ModBase

Search...

Protein-protein interaction databases

STRING

176279.SERP2398.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAW53239; AAW53239; SERP2398.

GeneID

3242404.

KEGG

ser:SERP2398.

PATRIC

19615683. VBIStaEpi130894_2329.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

NOG12793.

KO

K14195.

OMA

QEPTTLK.

Enzyme and pathway databases

BioCyc

SEPI176279:GJJB-2476-MONOMER.

Family and domain databases

InterPro

IPR011098. G5_dom.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
[Graphical view]

Pfam

PF07501. G5. 13 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.

PROSITE

PS51109. G5. 13 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5HKE8_STAEQ

Accession

Primary (citable) accession number: Q5HKE8

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)