Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5HKE8

- Q5HKE8_STAEQ

UniProt

Q5HKE8 - Q5HKE8_STAEQ

Protein
Submitted name:

Accumulation associated protein

Gene

aap

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi2035 – 20351ZincImported
    Metal bindingi2037 – 20371ZincImported
    Metal bindingi2091 – 20911Zinc; via tele nitrogenImported
    Metal bindingi2165 – 21651ZincImported
    Metal bindingi2219 – 22191ZincImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-2476-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Accumulation associated proteinImported
    Gene namesi
    Name:aapImported
    Ordered Locus Names:SERP2398Imported
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)Imported
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    Subcellular locationi

    Secretedcell wall SAAS annotation; Peptidoglycan-anchor SAAS annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wallUniRule annotation, Secreted

    PTM / Processingi

    Keywords - PTMi

    Peptidoglycan-anchorUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi176279.SERP2398.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FUMX-ray2.40A2017-2223[»]
    4FUNX-ray2.31A2017-2223[»]
    4FUOX-ray1.97A2017-2223[»]
    4FUPX-ray2.51A/B2017-2223[»]
    ProteinModelPortaliQ5HKE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG12793.
    KOiK14195.
    OMAiQSEPTKA.

    Family and domain databases

    InterProiIPR011098. G5_dom.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF07501. G5. 13 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS51109. G5. 13 hits.
    PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HKE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKRRQGPIN KKVDFLPNKL NKYSIRKFTV GTASILLGST LIFGSSSHEA     50
    KAAEEKQVDP ITQANQNDSS ERSLENTNQP TVNNEAPQMS STLQAEEGSN 100
    AEAPQSEPTK AEEGGNAEAA QSEPTKAEEG GNAEAPQSEP TKAEEGGNAE 150
    AAQSEPTKTE EGSNVKAAQS EPTKAEEGSN AEAPQSEPTK TEEGSNAKAA 200
    QSEPTKAEEG GNAEAAQSEP TKTEEGSNAE APQSEPTKAE EGGNAEAPQS 250
    EPTKTEEGGN AEAPNVPTIK ANSDNDTQTQ FSEAPTRNDL ARKEDIPAVS 300
    KNEELQSSQP NTDSKIEPTT SEPVNLNYSS PFMSLLSMPA DSSSNNTKNT 350
    IDIPPTTVKG RDNYDFYGRV DIESNPTDLN ATNLTRYNYG QPPGTTTAGA 400
    VQFKNQVSFD KDFDFNIRVA NNRQSNTTGA DGWGFMFSKK DGDDFLKNGG 450
    ILREKGTPSA AGFRIDTGYY NNDPLDKIQK QAGQGYRGYG TFVKNDSQGN 500
    TSKVGSGTPS TDFLNYADNT TNDLDGKFHG QKLNNVNLKY NASNQTFTAT 550
    YAGKTWTATL SELGLSPTDS YNFLVTSSQY GNGNSGTYAS GVMRADLDGA 600
    TLTYTPKAVD GDPIISTKEI PFNKKREFDP NLAPGTEKVV QKGEPGIETT 650
    TTPTYVNPNT GEKVGEGEPT EKITKQPVDE IVHYGGEEIK PGHKDEFDPN 700
    APKGSQTTQP GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD PITSTEEIPF 750
    DKKREFNPDL KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK 800
    ITKQPVDEIT EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE 850
    VVTPPVDDVT KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE 900
    PGTKTITTPT TKNPLTGEKV GEGEPTEKVT KQPVDEITEY GGEEIKPGHK 950
    DEFDPNAPKG SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS 1000
    TEEIPFDKKR EFDPNLAPGT EKVVQKGEPG TKTITTPTTK NPLTGEKVGE 1050
    GEPTEKVTKQ PVDEIVHYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK 1100
    NPDTGEVVTP PVDDVTKYGP VDGDPITSTE EIPFDKKREF DPNLAPGTEK 1150
    VVQKGEPGTK TITTPTTKNP LTGEKVGEGE PTEKVTKQPV DEIVHYGGEE 1200
    IKPGHKDEFD PNAPKGSQED VPGKPGVKNP DTGEVVTPPV DDVTKYGPVD 1250
    GDPITSTEEI PFDKKREFNP DLKPGEERVK QKGEPGTKTI TTPTTKNPLT 1300
    GEKVGEGEPT EKITKQPVDE ITEYGGEEIK PGHKDEFDPN APKGSQTTQP 1350
    GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD PITSTEEIPF DKKREFNPDL 1400
    KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIT 1450
    EYGGEEIKPG HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE VVTPPVDDVT 1500
    KYGPVDGDPI TSTEEIPFDK KREFNPDLKP GEERVKQKGE PGTKTITTPT 1550
    TKNPLTGEKV GEGEPTEKIT KQPVDEITEY GGEEIKPGHK DEFDPNAPKG 1600
    SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS TEEIPFDKKR 1650
    EFDPNLAPGT EKVVQKGEPG TKTITTPTTK NPLTGEKVGE GEPTEKITKQ 1700
    PVDEITEYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK NPDTGEVVTP 1750
    PVDDVTKYGP VDGDPITSTE EIPFDKKREF DPNLAPGTEK VVQKGEPGTK 1800
    TITTPTTKNP LTGEKVGEGE PTEKITKQPV DEIVHYGGEE IKTGHKDEFD 1850
    PNAPKGSQTT QPGKPGVKNP DTGEVVTPPV DDVTKYGPVD GDPITSTEEI 1900
    PFDKKREFDP NLAPGTEKVV QKGEPGTKTI TTPTTKNPLT GEKVGEGEPT 1950
    EKITKQPVDE IVHYGGEEIK PGHKDEFDPN APKGSQEDVP GKPGVKNPDT 2000
    GEVVTPPVDD VTKYGPVDGD SITSTEEIPF DKKREFDPNL APGTEKVVQK 2050
    GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIV HYGGEQIPQG 2100
    HKDEFDPNAP VDSKTEVPGK PGVKNPDTGE VVTPPVDDVT KYGPVDGDSI 2150
    TSTEEIPFDK KREFDPNLAP GTEKVVQKGE PGTKTITTPT TKNPLTGEKV 2200
    GEGKSTEKVT KQPVDEIVEY GPTKAEPGKP AEPGKPAEPG KPAEPGTPAE 2250
    PGKPAEPGTP AEPGKPAEPG KPAEPGKPAE PGKPAEPGTP AEPGTPAEPG 2300
    KPAEPGTPAE PGKPAEPGTP AEPGKPAESG KPVEPGTPAQ SGAPEQPNRS 2350
    MHSTDNKNQL PDTGENRQAN EGTLVGSLLA IVGSLFIFGR RKKGNEK 2397
    Length:2,397
    Mass (Da):255,612
    Last modified:February 15, 2005 - v1
    Checksum:i577FB0A4E5DDE15E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53239.1.
    RefSeqiYP_189945.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW53239; AAW53239; SERP2398.
    GeneIDi3242404.
    KEGGiser:SERP2398.
    PATRICi19615683. VBIStaEpi130894_2329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53239.1 .
    RefSeqi YP_189945.1. NC_002976.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FUM X-ray 2.40 A 2017-2223 [» ]
    4FUN X-ray 2.31 A 2017-2223 [» ]
    4FUO X-ray 1.97 A 2017-2223 [» ]
    4FUP X-ray 2.51 A/B 2017-2223 [» ]
    ProteinModelPortali Q5HKE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP2398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW53239 ; AAW53239 ; SERP2398 .
    GeneIDi 3242404.
    KEGGi ser:SERP2398.
    PATRICi 19615683. VBIStaEpi130894_2329.

    Phylogenomic databases

    eggNOGi NOG12793.
    KOi K14195.
    OMAi QSEPTKA.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-2476-MONOMER.

    Family and domain databases

    InterProi IPR011098. G5_dom.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF07501. G5. 13 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS51109. G5. 13 hits.
    PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62AImported.
    2. "Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms."
      Conrady D.G., Wilson J.J., Herr A.B.
      Proc. Natl. Acad. Sci. U.S.A. 110:E202-E211(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2017-2223 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiQ5HKE8_STAEQ
    AccessioniPrimary (citable) accession number: Q5HKE8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3