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Protein

Uncharacterized sensor-like histidine kinase SERP2405

Gene

SERP2405

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable member of the two-component regulatory system SERP2405/SERP2406. May activate SERP2406 by phosphorylation (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized sensor-like histidine kinase SERP2405 (EC:2.7.13.3)
Gene namesi
Ordered Locus Names:SERP2405
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Uncharacterized sensor-like histidine kinase SERP2405PRO_0000299129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei325 – 3251Phosphohistidine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2405.

Structurei

3D structure databases

ProteinModelPortaliQ5HKE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 512216Histidine kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2F. Bacteria.
COG2972. LUCA.
HOGENOMiHOG000279740.
OMAiWVEHRTI.
OrthoDBiEOG664CCC.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HKE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTYKPYRHQ LRRSLFASTI FPVFMVMIIG LISFYAIYIW VEHRTIHQHT
60 70 80 90 100
YQTQTELQRI DKHFHTFVTQ QQKQWRHVDL SHPTDITKMK RQLLKQVHQQ
110 120 130 140 150
PAILYYDLKG SSQSFTNNYE QLDTTKMYLI SKYRIDFKDD TYILKIYMSS
160 170 180 190 200
TPLLKNIKKN SGQSALIVDS YDTVLYTNDD RFSIGQKYQP PQFGFMNESL
210 220 230 240 250
KLNSHHAHLI IYKDIHETIE DGIALLVVMG VVLILLVIFG YISADRMAKR
260 270 280 290 300
QSEDIEAIVR KIDDAKNRHL GSYEPLKKHS ELEEINNYIY DLFESNEQLI
310 320 330 340 350
QSIEQTERRL RDIQLKEIER QFQPHFLFNT MQTIQYLIPL SPKVAQTVIQ
360 370 380 390 400
QLSQMLRYSL RTASHTVKLA EELSYIQQYV AIQNIRFDDM IQLYIDAPED
410 420 430 440 450
VQHQTIGKMM LQPLVENAIK HGRGSEPLKI TIRIRLTKRK LHILVHDNGI
460 470 480 490 500
GMSPSHLERV RQSLHHDVFD TTHLGLNHLH NRAIIQYGTY ARLHIFSRSH
510
QGTLMCYQIP LV
Length:512
Mass (Da):60,392
Last modified:February 15, 2005 - v1
Checksum:i50432E13C10FE2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53252.1.
RefSeqiWP_002505316.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53252; AAW53252; SERP2405.
KEGGiser:SERP2405.
PATRICi19615693. VBIStaEpi130894_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53252.1.
RefSeqiWP_002505316.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HKE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP2405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW53252; AAW53252; SERP2405.
KEGGiser:SERP2405.
PATRICi19615693. VBIStaEpi130894_2334.

Phylogenomic databases

eggNOGiENOG4105C2F. Bacteria.
COG2972. LUCA.
HOGENOMiHOG000279740.
OMAiWVEHRTI.
OrthoDBiEOG664CCC.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2483-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiY2405_STAEQ
AccessioniPrimary (citable) accession number: Q5HKE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 15, 2005
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.