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Q5HKD6 (MQO3_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase 3
EC=1.1.5.4
Alternative name(s):
MQO 3
Malate dehydrogenase [quinone] 3
Gene names
Name:mqo3
Ordered Locus Names:SERP2412
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Probable malate:quinone oxidoreductase 3 HAMAP MF_00212
PRO_0000128755

Sequences

Sequence LengthMass (Da)Tools
Q5HKD6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: F25DF5447374572D

FASTA49455,636
        10         20         30         40         50         60 
MSEANHKNIV VVGAGIIGTS VATMLSKVSP NWHIDMFERL EGAGIESSNE NNNAGTGHAA 

        70         80         90        100        110        120 
LCELNYTVEQ DDGSIDASKA QEINEQFELS RQFWGNLVKN GDISNPEEFI QPLPHISFVM 

       130        140        150        160        170        180 
GPTNVNFLRK RYETLRTLPM FDTIEYTEDM ETMRKWMPLM MENREPGHQM AASKIDEGTD 

       190        200        210        220        230        240 
VNYGALTRKL AHYLEQKSNV SLKYNHDVVD LTQREDGKWE VVVENRETKE KVTKIADKVF 

       250        260        270        280        290        300 
IGAGGHSIPL LQKSGVKQRE HLGGFPISGQ FLRCTNPDII KQHAAKVYSK EPQGKPPMTV 

       310        320        330        340        350        360 
PHLDTRYING KQTLLFGPYA NIGPKFLKFG SNLDLFESIK PYNITTMLAS AVKNVPLIKY 

       370        380        390        400        410        420 
SIDQMIKTKE GCMNYLRTFI PDAKDEDWEL YTAGKRVQVI KDSEQHGKGF VVFGTEVVNS 

       430        440        450        460        470        480 
DDNSMIALLG ESPGASTSLS VVLEVLEKNF ADDKEAWEPV VKEMVPTYGR SLINDEKLMR 

       490 
ETRRETSKNL HLNR

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000029 Genomic DNA. Translation: AAW53266.1.
RefSeqYP_189957.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HKD6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HKD6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000041981; EBSTAP00000040524; EBSTAG00000041979.
GeneID3242946.
GenomeReviewsGene locus SERP2412 in contig CP000029_GR.
KEGGser:SERP2412.
NMPDRfig|176279.3.peg.2139.
PATRIC19615709. VBIStaEpi130894_2342.
TIGRSERP2412.

Phylogenomic databases

eggNOGCOG0579.
GeneTreeEBGT00050000024300.
HOGENOMHBG289663.
OMAVAGSFYM.
ProtClustDBPRK13339.

Enzyme and pathway databases

BioCycSEPI176279:SERP2412-MONOMER.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO3_STAEQ
AccessionPrimary (citable) accession number: Q5HKD6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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