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Q5HKB7

- ARSC2_STAEQ

UniProt

Q5HKB7 - ARSC2_STAEQ

Protein

Protein ArsC 2

Gene

arsC2

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
    Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
    Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
    Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

    GO - Molecular functioni

    1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
    2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to arsenic-containing substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Arsenical resistance

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-2509-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ArsC 2UniRule annotation
    Alternative name(s):
    Arsenate reductase 2UniRule annotation (EC:1.20.4.-UniRule annotation)
    Arsenical pump modifier 2UniRule annotation
    Low molecular weight protein-tyrosine-phosphatase 2UniRule annotation (EC:3.1.3.48UniRule annotation)
    Gene namesi
    Name:arsC2UniRule annotation
    Ordered Locus Names:SERP2431
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 131131Protein ArsC 2PRO_0000162529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
    Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi176279.SERP2431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HKB7.
    SMRiQ5HKB7. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273093.
    KOiK03741.
    OMAiEMRIVIT.
    OrthoDBiEOG6JDWJC.

    Family and domain databases

    HAMAPiMF_01624. Arsenate_reduct.
    InterProiIPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5HKB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKKTIYFIC TGNSCRSQMA EGWGKKILGD EWQVYSGGIE AHGVNPKAIE    50
    AMKEVGIDIS NHTSNLIDQN ILHQSDLVVT LCSDADKNCP ILPPSVKKEH 100
    WGFDDPAGKP WSEFQRVRDE IKTAIESFKT R 131
    Length:131
    Mass (Da):14,693
    Last modified:February 15, 2005 - v1
    Checksum:i405C72DCE141F55C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53288.1.
    RefSeqiYP_189976.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW53288; AAW53288; SERP2431.
    GeneIDi3242360.
    KEGGiser:SERP2431.
    PATRICi19615743. VBIStaEpi130894_2359.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53288.1 .
    RefSeqi YP_189976.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HKB7.
    SMRi Q5HKB7. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP2431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW53288 ; AAW53288 ; SERP2431 .
    GeneIDi 3242360.
    KEGGi ser:SERP2431.
    PATRICi 19615743. VBIStaEpi130894_2359.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273093.
    KOi K03741.
    OMAi EMRIVIT.
    OrthoDBi EOG6JDWJC.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-2509-MONOMER.

    Family and domain databases

    HAMAPi MF_01624. Arsenate_reduct.
    InterProi IPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiARSC2_STAEQ
    AccessioniPrimary (citable) accession number: Q5HKB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3