SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5HK76

- HSDR_STAEQ

UniProt

Q5HK76 - HSDR_STAEQ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Type-1 restriction enzyme R protein

Gene
hsdR, SERP2474
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2747ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2552-MONOMER.

Protein family/group databases

REBASEi10764. SepRPORF2472P.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 restriction enzyme R protein (EC:3.1.21.3)
Alternative name(s):
Type I restriction enzyme R protein
Gene namesi
Name:hsdR
Ordered Locus Names:SERP2474
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Type-1 restriction enzyme R proteinPRO_0000077271Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Protein-protein interaction databases

STRINGi176279.SERP2474.

Structurei

3D structure databases

ProteinModelPortaliQ5HK76.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 418165Helicase ATP-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the HsdR family.

Phylogenomic databases

eggNOGiCOG0610.
HOGENOMiHOG000003518.
KOiK01153.
OMAiNNGYIWH.
OrthoDBiEOG6JTCB4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
IPR022625. TypeI_RM_Rsu_C.
[Graphical view]
PfamiPF12008. EcoR124_C. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HK76-1 [UniParc]FASTAAdd to Basket

« Hide

MVYQSEYALE NEVLQQLENL GYERVNIHNV EQLHDNFRTI INERHKEKLN    50
GKPLTDREFE RLMTGINGKS VFDSAMQLRD SYVLKRDDDT DLYLNFMNLK 100
QWCQNKFQVT NQISVKDKYK SRYDVTILIN GLPLVQIELK RSGVAITEAF 150
NQIERYRRQN YTGLFRYIQL FVVSNKMETR YYANSDREIF KGQMFYWSNE 200
QNERINYLKD FIEDFLESCH ISKMISRYMV VNETDKFLMA LRPYQVYAVE 250
AILNRALETN NNGYIWHTTG SGKTLTSFKA SQLLSQEENI KKVIFLVDRK 300
DLDNQTLAEF NKFQEDSVDF TDNTRKLLKQ LADPTLPLIV TTIQKMANAV 350
KSNHSVMESY KQDKVIFIID ECHRTQFGDM HRLIKQHFEN AQYFGFTGTP 400
RFEENKSQDG RATADIFDKC LHHYLIKDAI RDHNVLGFSV EYNQTFNSHE 450
DLDEEYISKI NTSEIWMADE RIEAVCRHLI SNYHKKTDNG NYTSMFAVQS 500
IPMAIKYYDT FQRLKNEGVH DLNVATIFTY QANEDAQEDE NHVHSREVLD 550
RIMNDYNQTF KTNYNTDNFE GYFSDVSKRM KEVVRDDKID ILIVVNMFLT 600
GFDSKKLNTL YVDKNLKHHD LIQAYSRTNR VEKERKPYGN IVCYRDLKKQ 650
TDEAIEIFSQ TDNTDTVLSL SYEEYLDNFK DILQDVFQLA PTPLDVDKLE 700
AEDLKKEFVI SFRDLSNTLI KLKTFDEFQF TEDELGIAEQ TYEDYKGKYL 750
NIYEEVMRGK KVDGEEGVSV LDDIDFQVEL MRNDLINVKY IMDLIGQINL 800
SDAKARDEKR HQIHKLLDKA DDQQLRLKAD LIRSFLDKVV PSLKEDSDIN 850
EAYYEFEDKE KTKEIDAFAE QKAFSAMLLN EAVNEYEYSG NIDRKSIGQN 900
ISEPFMKRKR KTDQIIQFIE DTVEKYGVVE 930
Length:930
Mass (Da):109,659
Last modified:February 15, 2005 - v1
Checksum:iAFE422D1D08A0A1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53360.1.
RefSeqiWP_002489617.1. NC_002976.3.
YP_190017.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53360; AAW53360; SERP2474.
GeneIDi3242316.
KEGGiser:SERP2474.
PATRICi19615821. VBIStaEpi130894_2398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53360.1 .
RefSeqi WP_002489617.1. NC_002976.3.
YP_190017.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HK76.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP2474.

Protein family/group databases

REBASEi 10764. SepRPORF2472P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW53360 ; AAW53360 ; SERP2474 .
GeneIDi 3242316.
KEGGi ser:SERP2474.
PATRICi 19615821. VBIStaEpi130894_2398.

Phylogenomic databases

eggNOGi COG0610.
HOGENOMi HOG000003518.
KOi K01153.
OMAi NNGYIWH.
OrthoDBi EOG6JTCB4.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-2552-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
IPR022625. TypeI_RM_Rsu_C.
[Graphical view ]
Pfami PF12008. EcoR124_C. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00348. hsdR. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiHSDR_STAEQ
AccessioniPrimary (citable) accession number: Q5HK76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and magnesium as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi