Q5HJR1 (NORG_STAAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator NorG

Gene names

Name:	norG
Ordered Locus Names:	SACOL0091

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity By similarity.
Cofactor	Pyridoxal phosphate Potential.
Sequence similarities	In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Contains 1 HTH gntR-type DNA-binding domain.
Sequence caution	The sequence AAW38735.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding Pyridoxal phosphate
Molecular function	Activator Aminotransferase Repressor Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 442	441	HTH-type transcriptional regulator NorG		PRO_0000305320
Regions
	Domain	2 – 46	45	HTH gntR-type
	DNA binding	6 – 25	20	H-T-H motif By similarity
Amino acid modifications
	Modified residue	288	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HJR1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 340EC99245972319	FASTA	442	51,303
	10 20 30 40 50 60 MKIPSHRQLA IQYNVNRVTI IKSIELLEAE GFIYTKVGSG TYVNDYLNEA HITNKWSEMM 70 80 90 100 110 120 LWSSQQRSQY TVQLINKIET DDSYIHISKG ELGISLMPHI QLKKAMSNTA SHIEDLSFGY 130 140 150 160 170 180 NNGYGYIKLR DIIVERMSKQ GINVGRENVM ITSGALHAIQ LLSIGFLGQD AIIISNTPSY 190 200 210 220 230 240 IHSTNVFEQL NFRHIDVPYN QINEIDTIID RFINFKNKAI YIEPRFNNPT GRSLTNEQKK 250 260 270 280 290 300 NIITYSERHN IPIIEDDIFR DIFFSDPTPS IKTYDKLGKV IHISSFSKTI APAIRIGWIV 310 320 330 340 350 360 ASEKIIEQLA DVRMQIDYGS SILSQMVVYE MLKNKSYDKH LVKLRYVLKD KRDFMLNILN 370 380 390 400 410 420 NLFKDIAHWE VPSGGYFVWL VFKIDIDIKY LFYELLSKEK ILINPGYIYG SKEKSIRLSF 430 440 AFESNENIKH ALYKIYTYVK KV

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: COL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW38735.1. Different initiation.
RefSeq	YP_184996.1. NC_002951.2.
3D structure databases
ProteinModelPortal	Q5HJR1.
SMR	Q5HJR1. Positions 85-441.
ModBase	Search...
Protein-protein interaction databases
STRING	93062.SACOL0091.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW38735; AAW38735; SACOL0091.
GeneID	3236865.
KEGG	sac:SACOL0091.
PATRIC	19526440. VBIStaAur112458_0086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1167.
HOGENOM	HOG000223054.
OMA	AKVKYIW.
ProtClustDB	CLSK884402.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR000524. Tscrpt_reg_HTH_GntR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. PF00392. GntR. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NORG_STAAC

Accession

Primary (citable) accession number: Q5HJR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program