Reviewed, UniProtKB/Swiss-Prot Q5HJK3 (ALDA_STAAC)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase aldA
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	SACOL0154

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Putative aldehyde dehydrogenase aldA		PRO_0000056455
Regions
	Nucleotide binding	212 – 218	7	NAD By similarity
Sites
	Active site	256	1	By similarity
	Active site	290	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HJK3-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: DCBE4F433645A52A	FASTA	495	53,659
	10 20 30 40 50 60 MAVNVRDYIA ENYGLFINGE FVKGSSDETI EVTNPATGET LSHITRAKDK DVDHAVKVAQ 70 80 90 100 110 120 EAFESWSLTS KSERAQMLRD IGDKLMAQKD KIAMIETLNN GKPIRETTAI DIPFAARHFH 130 140 150 160 170 180 YFASVIETEE GTVNDIDKDT MSIVRHEPIG VVGAVVAWNF PMLLAAWKIA PAIAAGNTIV 190 200 210 220 230 240 IQPSSSTPLS LLEVAKIFQE VLPKGVVNIL TGKGSESGNA IFNHDGVDKL SFTGSTDVGY 250 260 270 280 290 300 QVAEAAAKHL VPATLELGGK SANIILDDAN LDLAVEGIQL GILFNQGEVC SAGSRLLVHE 310 320 330 340 350 360 KIYDQLVPRL QEAFSNIKVG NPQDEATQMG SQTGKDQLDK IQSYIDAAKE SDAQILAGGH 370 380 390 400 410 420 RLTENGLDKG FFFEPTLIAV PDNHHKLAQE EIFGPVLTVI KVKDDQEAID IANDSEYGLA 430 440 450 460 470 480 GGVFSQNITR ALNIAKAVRT GRIWINTYNQ VPEGAPFGGY KKSGIGRETY KGALSNYQQV 490 KNIYIDTSNA LKGLY

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW37451.1.
RefSeq	YP_185054.1.
3D structure databases
SMR	Q5HJK3. Positions 14-489.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HJK3.
Genome annotation databases
GeneID	3238707.
GenomeReviews	Gene locus SACOL0154 in contig CP000046_GR.
KEGG	sac:SACOL0154.
TIGR	SACOL0154.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	EDSNANI.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL0154-MONOMER.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDA_STAAC

Accession

Primary (citable) accession number: Q5HJK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)