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Q5HIL2 (SLE1_STAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase sle1

EC=3.5.1.28
Gene names
Name:sle1
Synonyms:aaa
Ordered Locus Names:SACOL0507
OrganismStaphylococcus aureus (strain COL) [Complete proteome] [HAMAP]
Taxonomic identifier93062 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted By similarity. Cell surface By similarity.

Sequence similarities

Contains 3 LysM repeats.

Contains 1 peptidase C51 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 334309N-acetylmuramoyl-L-alanine amidase sle1
PRO_0000231622

Regions

Repeat29 – 7143LysM 1
Repeat93 – 13543LysM 2
Repeat160 – 20243LysM 3
Domain210 – 334125Peptidase C51

Sequences

Sequence LengthMass (Da)Tools
Q5HIL2 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 4C1E30AD9DE61D36

FASTA33435,836
        10         20         30         40         50         60 
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK LKSLNNLTSN 

        70         80         90        100        110        120 
LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS LSLIASKYGT TYQNIMRLNG 

       130        140        150        160        170        180 
LNNFFIYPGQ KLKVSGTASS SNAASNSSRP STNSGGGSYY TVQAGDSLSL IASKYGTTYQ 

       190        200        210        220        230        240 
KIMSLNGLNN FFIYPGQKLK VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF 

       250        260        270        280        290        300 
NRRAEIGKGI STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND 

       310        320        330 
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000046 Genomic DNA. Translation: AAW37626.1.
RefSeqYP_185395.1. NC_002951.2.

3D structure databases

ProteinModelPortalQ5HIL2.
SMRQ5HIL2. Positions 26-207, 228-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93062.SACOL0507.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW37626; AAW37626; SACOL0507.
GeneID3237082.
KEGGsac:SACOL0507.
PATRIC19527256. VBIStaAur112458_0494.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3942.
HOGENOMHOG000279823.
OMAEMNYSAS.
OrthoDBEOG6GTZPF.
ProtClustDBCLSK884669.

Enzyme and pathway databases

BioCycSAUR93062:GCEP-493-MONOMER.

Family and domain databases

Gene3D3.10.350.10. 3 hits.
InterProIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMSSF54106. SSF54106. 3 hits.
PROSITEPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLE1_STAAC
AccessionPrimary (citable) accession number: Q5HIL2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries