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Q5HIB4 (SDRC_STAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine-aspartate repeat-containing protein C
Gene names
Name:sdrC
Ordered Locus Names:SACOL0608
OrganismStaphylococcus aureus (strain COL) [Complete proteome] [HAMAP]
Taxonomic identifier93062 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length947 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell surface-associated protein which possibly mediates interactions of S.aureus with components of the extracellular matrix of higher eukaryotes. May bind calcium By similarity.

Subcellular location

Secretedcell wall; Peptidoglycan-anchor Potential.

Sequence similarities

Belongs to the serine-aspartate repeat-containing protein (SDr) family.

Contains 2 CNA-B domains.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   LigandCalcium
   PTMPeptidoglycan-anchor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 Potential
Chain51 – 913863Serine-aspartate repeat-containing protein C
PRO_0000281390
Propeptide914 – 94734Removed by sortase Potential
PRO_0000281391

Regions

Domain496 – 606111CNA-B 1
Domain607 – 717111CNA-B 2
Region51 – 495445Ligand binding A region
Motif910 – 9145LPXTG sorting signal Potential
Compositional bias65 – 167103Thr-rich
Compositional bias718 – 887170Asp/Ser-rich

Amino acid modifications

Modified residue9131Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

Sequence LengthMass (Da)Tools
Q5HIB4 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 389C5E6432A97F5E

FASTA947102,916
        10         20         30         40         50         60 
MNNKKTATNR KGMIPNRLNK FSIRKYSVGT ASILVGTTLI FGLSGHEAKA AEHTNGELNQ 

        70         80         90        100        110        120 
SKNETTAPSE NKTTKKVDSR QLKDNTQTAT ADQPKVTMSD SATVKETSSN MQSPQNATAN 

       130        140        150        160        170        180 
QSTTKTSNVT TNDKSSTTYS NETDKSNLTQ AKDVSTTPKT TTIKPRTLNR MAVNTVAAPQ 

       190        200        210        220        230        240 
QGTNVNDKVH FSNIDIAIDK GHVNQTTGKT EFWATSSDVL KLKANYTIDD SVKEGDTFTF 

       250        260        270        280        290        300 
KYGQYFRPGS VRLPSQTQNL YNAQGNIIAK GIYDSTTNTT TYTFTNYVDQ YTNVRGSFEQ 

       310        320        330        340        350        360 
VAFAKRKNAT TDKTAYKMEV TLGNDTYSEE IIVDYGNKKA QPLISSTNYI NNEDLSRNMT 

       370        380        390        400        410        420 
AYVNQPKNTY TKQTFVTNLT GYKFNPNAKN FKIYEVTDQN QFVDSFTPDT SKLKDVTDQF 

       430        440        450        460        470        480 
DVIYSNDNKT ATVDLMKGQT SSNKQYIIQQ VAYPDNSSTD NGKIDYTLDT DKTKYSWSNS 

       490        500        510        520        530        540 
YSNVNGSSTA NGDQKKYNLG DYVWEDTNKD GKQDANEKGI KGVYVILKDS NGKELDRTTT 

       550        560        570        580        590        600 
DENGKYQFTG LSNGTYSVEF STPAGYTPTT ANVGTDDAVD SDGLTTTGVI KDADNMTLDS 

       610        620        630        640        650        660 
GFYKTPKYSL GDYVWYDSNK DGKQDSTEKG IKGVKVTLQN EKGEVIGTTE TDENGKYRFD 

       670        680        690        700        710        720 
NLDSGKYKVI FEKPAGLTQT GTNTTEDDKD ADGGEVDVTI TDHDDFTLDN GYYEEETSDS 

       730        740        750        760        770        780 
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 

       790        800        810        820        830        840 
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 

       850        860        870        880        890        900 
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDNDSDS DSDSDSDAGK HTPAKPMSTV 

       910        920        930        940 
KDQHKTAKAL PETGSENNNS NNGTLFGGLF AALGSLLLFG RRKKQNK 

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References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000046 Genomic DNA. Translation: AAW37717.1.
RefSeqYP_185493.1. NC_002951.2.

3D structure databases

ProteinModelPortalQ5HIB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93062.SACOL0608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW37717; AAW37717; SACOL0608.
GeneID3236353.
KEGGsac:SACOL0608.
PATRIC19527476. VBIStaAur112458_0591.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000279832.
KOK14194.
OMADNTSVKE.
OrthoDBEOG6RNQ8T.

Enzyme and pathway databases

BioCycSAUR93062:GCEP-606-MONOMER.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR011252. Fibrogen-bd_dom1.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR013783. Ig-like_fold.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamPF05738. Cna_B. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMSSF49401. SSF49401. 2 hits.
TIGRFAMsTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ5HIB4.

Entry information

Entry nameSDRC_STAAC
AccessionPrimary (citable) accession number: Q5HIB4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families