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Protein

Putative acetyl-CoA C-acetyltransferase VraB

Gene

vraB

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Acyl-thioester intermediateBy similarity
Active sitei338 – 3381Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acetyl-CoA C-acetyltransferase VraB (EC:2.3.1.-)
Gene namesi
Name:vraB
Ordered Locus Names:SACOL0622
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Putative acetyl-CoA C-acetyltransferase VraBPRO_0000206426Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0622.

Structurei

3D structure databases

ProteinModelPortaliQ5HIA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
KOiK00626.
OMAiSHERSWE.
OrthoDBiEOG68M4GV.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00737. THIOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HIA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQAVIVAAK RTAFGKYGGT LKHLEPEQLL KPLFQHFKEK YPEVISKIDD
60 70 80 90 100
VVLGNVVGNG GNIARKALLE AGLKDSIPGV TIDRQCGSGL ESVQYACRMI
110 120 130 140 150
QAGAGKVYIA GGVESTSRAP WKIKRPHSVY ETALPEFYER ASFAPEMSDP
160 170 180 190 200
SMIQGAENVA KMYDVSRGLQ DEFAYRSHQL TAENVKNGNI SQEILPITVK
210 220 230 240 250
GEIFNTDESL KSHIPKDNFG RFKPVIKGGT VTAANSCMKN DGAVLLLIME
260 270 280 290 300
KDMAYELGFE HGLLFKDGVT VGVDSNFPGI GPVPAISNLL KRNQLTIENI
310 320 330 340 350
EVIEINEAFS AQVVACQQAL NISNTQLNIW GGALASGHPY GASGAQLVTR
360 370
LFYMFDKETM IASMGIGGGL GNAALFTRF
Length:379
Mass (Da):41,022
Last modified:February 15, 2005 - v1
Checksum:i477876C11342D392
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37731.1.
RefSeqiWP_001070681.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37731; AAW37731; SACOL0622.
KEGGisac:SACOL0622.
PATRICi19527506. VBIStaAur112458_0606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37731.1.
RefSeqiWP_001070681.1. NC_002951.2.

3D structure databases

ProteinModelPortaliQ5HIA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW37731; AAW37731; SACOL0622.
KEGGisac:SACOL0622.
PATRICi19527506. VBIStaAur112458_0606.

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
KOiK00626.
OMAiSHERSWE.
OrthoDBiEOG68M4GV.

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-620-MONOMER.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00737. THIOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: COL.

Entry informationi

Entry nameiVRAB_STAAC
AccessioniPrimary (citable) accession number: Q5HIA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 15, 2005
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.