Reviewed, UniProtKB/Swiss-Prot Q5HI32 (TAGA_STAAC)

Names and origin

Protein names

Recommended name:
    Putative N-acetylmannosaminyltransferase
    EC=2.4.1.187
Alternative name(s):
    UDP-N-acetylmannosamine transferase
    N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase
    Major teichoic acid biosynthesis protein A

Gene names

Name:	tagA
Ordered Locus Names:	SACOL0693

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential.
Catalytic activity	UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol.
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Secreted
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative N-acetylmannosaminyltransferase		PRO_0000208441

Sequences

	Sequence		Length	Mass (Da)
	Q5HI32-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 99C014388CFED0BB	FASTA	254	29,133
	10 20 30 40 50 60 MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP EIVNYATTHQ 70 80 90 100 110 120 AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM DECLKIAHVN HQKVFLLGAT 130 140 150 160 170 180 NEVVEAAQYA LQQRYPNISF AHHHGYIDLE DETVVKRIKL FKPDYIFVGM GFPKQEEWIM 190 200 210 220 230 240 THENQFESTV MMGVGGSLEV FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM 250 YKIAKAKRKI KKAK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW37757.1.
RefSeq	YP_185575.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HI32.
Protein family/group databases
CAZy	GT26. Glycosyltransferase Family 26.
Genome annotation databases
GeneID	3236583.
GenomeReviews	Gene locus SACOL0693 in contig CP000046_GR.
KEGG	sac:SACOL0693.
TIGR	SACOL0693.
Phylogenomic databases
eggNOG	COG1922.
HOGENOM	HBG685240.
OMA	NPEIVDY.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL0693-MONOMER.
Family and domain databases
InterPro	IPR004629. WecB_TagA_CpsF. [Graphical view]
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. wecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TAGA_STAAC

Accession

Primary (citable) accession number: Q5HI32

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)