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Q5HHC2

- G6PI_STAAC

UniProt

Q5HHC2 - G6PI_STAAC

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei285 – 2851Proton donorUniRule annotation
    Active sitei306 – 3061UniRule annotation
    Active sitei420 – 4201UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSAUR93062:GCEP-953-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:SACOL0966
    OrganismiStaphylococcus aureus (strain COL)
    Taxonomic identifieri93062 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000530: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Glucose-6-phosphate isomerasePRO_0000180726Add
    BLAST

    Proteomic databases

    PRIDEiQ5HHC2.

    Interactioni

    Protein-protein interaction databases

    STRINGi93062.SACOL0966.

    Structurei

    Secondary structure

    1
    443
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 75
    Helixi11 – 133
    Helixi17 – 215
    Helixi24 – 3613
    Helixi42 – 443
    Turni46 – 494
    Helixi50 – 534
    Helixi56 – 7217
    Beta strandi74 – 796
    Helixi82 – 843
    Helixi86 – 9510
    Beta strandi107 – 1148
    Helixi117 – 12610
    Helixi127 – 1293
    Beta strandi132 – 1376
    Beta strandi139 – 1413
    Helixi144 – 16118
    Helixi163 – 1697
    Beta strandi170 – 1745
    Helixi180 – 1889
    Beta strandi191 – 1944
    Helixi201 – 2033
    Helixi208 – 2169
    Helixi221 – 23414
    Helixi240 – 2423
    Helixi244 – 25714
    Beta strandi262 – 2698
    Helixi270 – 2723
    Helixi273 – 28715
    Beta strandi295 – 3006
    Helixi303 – 3064
    Helixi309 – 3146
    Beta strandi319 – 32810
    Helixi345 – 3484
    Helixi353 – 37018
    Beta strandi375 – 3817
    Helixi385 – 40622
    Helixi414 – 4163
    Helixi417 – 42610
    Helixi433 – 4419

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FF1X-ray1.65A/B1-443[»]
    ProteinModelPortaliQ5HHC2.
    SMRiQ5HHC2. Positions 4-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5HHC2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiGVESYKR.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HHC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHIQLDFSK TLEFFGEHEL KQQQEIVKSI HKTIHEGTGA GSDFLGWVDL    50
    PVDYDKEEFS RIVEASKRIK ENSDVLVVIG IGGSYLGARA AIEMLTSSFR 100
    NSNEYPEIVF VGNHLSSTYT KELVDYLADK DFSVNVISKS GTTTEPAVAF 150
    RLFKQLVEER YGKEEAQKRI FATTDKEKGA LKQLATNEGY ETFIVPDDVG 200
    GRYSVLTAVG LLPIATAGIN IEAMMIGAAK AREELSSDKL EENIAYQYAT 250
    IRNILYAKGY TTEMLINYEP SMQYFNEWWK QLFGESEGKD FKGIYPSSAN 300
    YTTDLHSLGQ YVQEGRRFLF ETVVKVNHPK YDITIEKDSD DLDGLNYLAG 350
    KTIDEVNTKA FEGTLLAHTD GGVPNMVVNI PQLDEETFGY VVYFFELACA 400
    MSGYQLGVNP FNQPGVEAYK QNMFALLGKP GFEDLKKELE ERL 443
    Length:443
    Mass (Da):49,808
    Last modified:February 15, 2005 - v1
    Checksum:iDF9A8E633F8BD099
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37934.1.
    RefSeqiYP_185835.1. NC_002951.2.

    Genome annotation databases

    EnsemblBacteriaiAAW37934; AAW37934; SACOL0966.
    GeneIDi3237943.
    KEGGisac:SACOL0966.
    PATRICi19528174. VBIStaAur112458_0942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37934.1 .
    RefSeqi YP_185835.1. NC_002951.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FF1 X-ray 1.65 A/B 1-443 [» ]
    ProteinModelPortali Q5HHC2.
    SMRi Q5HHC2. Positions 4-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93062.SACOL0966.

    Proteomic databases

    PRIDEi Q5HHC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW37934 ; AAW37934 ; SACOL0966 .
    GeneIDi 3237943.
    KEGGi sac:SACOL0966.
    PATRICi 19528174. VBIStaAur112458_0942.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi GVESYKR.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci SAUR93062:GCEP-953-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5HHC2.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: COL.

    Entry informationi

    Entry nameiG6PI_STAAC
    AccessioniPrimary (citable) accession number: Q5HHC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3