Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei285Proton donorUniRule annotation1
Active sitei306UniRule annotation1
Active sitei420UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:SACOL0966
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807261 – 443Glucose-6-phosphate isomeraseAdd BLAST443

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0966.

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi11 – 13Combined sources3
Helixi17 – 21Combined sources5
Helixi24 – 36Combined sources13
Helixi42 – 44Combined sources3
Turni46 – 49Combined sources4
Helixi50 – 53Combined sources4
Helixi56 – 72Combined sources17
Beta strandi74 – 79Combined sources6
Helixi82 – 84Combined sources3
Helixi86 – 95Combined sources10
Beta strandi107 – 114Combined sources8
Helixi117 – 126Combined sources10
Helixi127 – 129Combined sources3
Beta strandi132 – 137Combined sources6
Beta strandi139 – 141Combined sources3
Helixi144 – 161Combined sources18
Helixi163 – 169Combined sources7
Beta strandi170 – 174Combined sources5
Helixi180 – 188Combined sources9
Beta strandi191 – 194Combined sources4
Helixi201 – 203Combined sources3
Helixi208 – 216Combined sources9
Helixi221 – 234Combined sources14
Helixi240 – 242Combined sources3
Helixi244 – 257Combined sources14
Beta strandi262 – 269Combined sources8
Helixi270 – 272Combined sources3
Helixi273 – 287Combined sources15
Beta strandi295 – 300Combined sources6
Helixi303 – 306Combined sources4
Helixi309 – 314Combined sources6
Beta strandi319 – 328Combined sources10
Helixi345 – 348Combined sources4
Helixi353 – 370Combined sources18
Beta strandi375 – 381Combined sources7
Helixi385 – 406Combined sources22
Helixi414 – 416Combined sources3
Helixi417 – 426Combined sources10
Helixi433 – 441Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FF1X-ray1.65A/B1-443[»]
ProteinModelPortaliQ5HHC2.
SMRiQ5HHC2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5HHC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HHC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIQLDFSK TLEFFGEHEL KQQQEIVKSI HKTIHEGTGA GSDFLGWVDL
60 70 80 90 100
PVDYDKEEFS RIVEASKRIK ENSDVLVVIG IGGSYLGARA AIEMLTSSFR
110 120 130 140 150
NSNEYPEIVF VGNHLSSTYT KELVDYLADK DFSVNVISKS GTTTEPAVAF
160 170 180 190 200
RLFKQLVEER YGKEEAQKRI FATTDKEKGA LKQLATNEGY ETFIVPDDVG
210 220 230 240 250
GRYSVLTAVG LLPIATAGIN IEAMMIGAAK AREELSSDKL EENIAYQYAT
260 270 280 290 300
IRNILYAKGY TTEMLINYEP SMQYFNEWWK QLFGESEGKD FKGIYPSSAN
310 320 330 340 350
YTTDLHSLGQ YVQEGRRFLF ETVVKVNHPK YDITIEKDSD DLDGLNYLAG
360 370 380 390 400
KTIDEVNTKA FEGTLLAHTD GGVPNMVVNI PQLDEETFGY VVYFFELACA
410 420 430 440
MSGYQLGVNP FNQPGVEAYK QNMFALLGKP GFEDLKKELE ERL
Length:443
Mass (Da):49,808
Last modified:February 15, 2005 - v1
Checksum:iDF9A8E633F8BD099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37934.1.
RefSeqiWP_000148855.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37934; AAW37934; SACOL0966.
KEGGisac:SACOL0966.
PATRICi19528174. VBIStaAur112458_0942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37934.1.
RefSeqiWP_000148855.1. NC_002951.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FF1X-ray1.65A/B1-443[»]
ProteinModelPortaliQ5HHC2.
SMRiQ5HHC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW37934; AAW37934; SACOL0966.
KEGGisac:SACOL0966.
PATRICi19528174. VBIStaAur112458_0942.

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

EvolutionaryTraceiQ5HHC2.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_STAAC
AccessioniPrimary (citable) accession number: Q5HHC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.