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Q5HHC2 (G6PI_STAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:SACOL0966
OrganismStaphylococcus aureus (strain COL) [Complete proteome] [HAMAP]
Taxonomic identifier93062 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180726

Sites

Active site2851Proton donor By similarity
Active site3061 By similarity
Active site4201 By similarity

Secondary structure

1 ....................................................................... 443
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5HHC2 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: DF9A8E633F8BD099

FASTA44349,808
        10         20         30         40         50         60 
MTHIQLDFSK TLEFFGEHEL KQQQEIVKSI HKTIHEGTGA GSDFLGWVDL PVDYDKEEFS 

        70         80         90        100        110        120 
RIVEASKRIK ENSDVLVVIG IGGSYLGARA AIEMLTSSFR NSNEYPEIVF VGNHLSSTYT 

       130        140        150        160        170        180 
KELVDYLADK DFSVNVISKS GTTTEPAVAF RLFKQLVEER YGKEEAQKRI FATTDKEKGA 

       190        200        210        220        230        240 
LKQLATNEGY ETFIVPDDVG GRYSVLTAVG LLPIATAGIN IEAMMIGAAK AREELSSDKL 

       250        260        270        280        290        300 
EENIAYQYAT IRNILYAKGY TTEMLINYEP SMQYFNEWWK QLFGESEGKD FKGIYPSSAN 

       310        320        330        340        350        360 
YTTDLHSLGQ YVQEGRRFLF ETVVKVNHPK YDITIEKDSD DLDGLNYLAG KTIDEVNTKA 

       370        380        390        400        410        420 
FEGTLLAHTD GGVPNMVVNI PQLDEETFGY VVYFFELACA MSGYQLGVNP FNQPGVEAYK 

       430        440 
QNMFALLGKP GFEDLKKELE ERL

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000046 Genomic DNA. Translation: AAW37934.1.
RefSeqYP_185835.1. NC_002951.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FF1X-ray1.65A/B1-443[»]
ProteinModelPortalQ5HHC2.
SMRQ5HHC2. Positions 4-443.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HHC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000009509; EBSTAP00000009244; EBSTAG00000009508.
GeneID3237943.
GenomeReviewsGene locus SACOL0966 in contig CP000046_GR.
KEGGsac:SACOL0966.
PATRIC19528174. VBIStaAur112458_0942.
TIGRSACOL0966.

Phylogenomic databases

eggNOGCOG0166.
GeneTreeEBGT00050000024507.
HOGENOMHBG615843.
OMADNLDGLN.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycSAUR93062:SACOL0966-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STAAC
AccessionPrimary (citable) accession number: Q5HHC2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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