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Protein

Serine protease HtrA-like

Gene

SACOL1028

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei504 – 5041Charge relay systemSequence analysis
Active sitei534 – 5341Charge relay systemSequence analysis
Active sitei619 – 6191Charge relay systemSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-1013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease HtrA-like (EC:3.4.21.-)
Gene namesi
Ordered Locus Names:SACOL1028
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Serine protease HtrA-likePRO_0000252465Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL1028.

Structurei

3D structure databases

ProteinModelPortaliQ5HH63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini680 – 73354PDZAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 PDZ (DHR) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000279952.
OMAiRNMAIND.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HH63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGKKHVIP KSQYRRKRRE FFHNEDREEN LNQHQDKQNI DNTTSKKADK
60 70 80 90 100
QIHKDSIDKH ERFKNSLSSH LEQRNRDVNE NKAEESKSNQ DSKSAYNRDH
110 120 130 140 150
YLTDDVSKKQ NSLDSVDQDT EKSKYYEQNS EATLSTKSTD KVESTEMRKL
160 170 180 190 200
SSDKNKVGHE EQHVLSKPSE HDKETRIDSE SSRTDSDSSM QTEKIKKDSS
210 220 230 240 250
DGNKSSNLKS EVISDKSNTV PKLSESDDEV NNQKPLTLPE EQKLKRQQSQ
260 270 280 290 300
NEQTKTYTYG DSEQNDKSNH ENDLSHHIPS ISDDKDNVMR ENHIVDDNPD
310 320 330 340 350
NDINTPSLSK TDDDRKLDEK IHVEDKHKQN ADSSETVGYQ SQSTASHRST
360 370 380 390 400
EKRNISINDH DKLNGQKTNT KTSANNNQKK ATSKLNKGRA TNNNYSDILK
410 420 430 440 450
KFWMMYWPKL VILMGIIILI VILNAIFNNV NKNDRMNDNN DADAQKYTTT
460 470 480 490 500
MKNANNTVKS VVTVENETSK DSSLPKDKAS QDEVGSGVVY KKSGDTLYIV
510 520 530 540 550
TNAHVVGDKE NQKITFSNNK SVVGKVLGKD KWSDLAVVKA TSSDSSVKEI
560 570 580 590 600
AIGDSNNLVL GEPILVVGNP LGVDFKGTVT EGIISGLNRN VPIDFDKDNK
610 620 630 640 650
YDMLMKAFQI DASVNPGNSG GAVVNREGKL IGVVAAKISM PNVENMSFAI
660 670 680 690 700
PVNEVQKIVK DLETKGKIDY PDVGVKMKNI ASLNSFERQA VKLPGKVKNG
710 720 730 740 750
VVVDQVDNNG LADQSGLKKG DVITELDGKL LEDDLRFRQI IFSHKDDLKS
760
ITAKIYRDGK EKEINIKLK
Length:769
Mass (Da):86,432
Last modified:February 15, 2005 - v1
Checksum:i7948E23EAD17CEBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW36494.1.
RefSeqiWP_000351031.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW36494; AAW36494; SACOL1028.
KEGGisac:SACOL1028.
PATRICi19528292. VBIStaAur112458_1001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW36494.1.
RefSeqiWP_000351031.1. NC_002951.2.

3D structure databases

ProteinModelPortaliQ5HH63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL1028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW36494; AAW36494; SACOL1028.
KEGGisac:SACOL1028.
PATRICi19528292. VBIStaAur112458_1001.

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000279952.
OMAiRNMAIND.

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-1013-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHTRAL_STAAC
AccessioniPrimary (citable) accession number: Q5HH63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.