Reviewed,
UniProtKB/Swiss-Prot Q5HH10 (PUR2_STAAC)
Last modified
February 9, 2010.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylamine--glycine ligase EC=6.3.4.13 Alternative name(s): GARS Glycinamide ribonucleotide synthetase Phosphoribosylglycinamide synthetase | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 93062 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 415 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP MF_00138 |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP MF_00138 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP MF_00138 |
| Sequence similarities | Belongs to the GARS family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW phosphoribosylamine-glycine ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 415 | 415 | Phosphoribosylamine--glycine ligase HAMAP MF_00138 | PRO_0000151478 | |||||
Regions | |||||||||
| Domain | 108 – 311 | 204 | ATP-grasp | ||||||
| Nucleotide binding | 134 – 191 | 58 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 281 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 283 | 1 | Magnesium or manganese By similarity | ||||||
Sequences
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References
| [1] | "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. Fraser C.M.J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000046 Genomic DNA. Translation: AAW37963.1. |
| RefSeq | YP_185947.1. |
3D structure databases | |
| SMR | Q5HH10. Positions 1-413. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5HH10. |
Genome annotation databases | |
| GeneID | 3236107. |
| GenomeReviews | Gene locus SACOL1083 in contig CP000046_GR. |
| KEGG | sac:SACOL1083. |
| TIGR | SACOL1083. |
Phylogenomic databases | |
| eggNOG | COG0151. |
| HOGENOM | HBG404060. |
| OMA | FSLMAFV. |
Enzyme and pathway databases | |
| BioCyc | SAUR93062:SACOL1083-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00138. GARS. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR020561. PRibGlycinamid_synth_ATP-grasp. IPR000115. PRibGlycinamide_synth. IPR020560. PRibGlycinamide_synth_C-dom. IPR020559. PRibGlycinamide_synth_CS. IPR020562. PRibGlycinamide_synth_N-dom. IPR011054. Rudment_hybrid_motif. [Graphical view] |
| Gene3D | G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF01071. GARS_A. 1 hit. PF02843. GARS_C. 1 hit. PF02844. GARS_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00877. purD. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00184. GARS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR2_STAAC | ||||||||
| Accession | Primary (citable) accession number: Q5HH10 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


