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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139GTPUniRule annotation1
Binding sitei143GTPUniRule annotation1
Binding sitei187GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 25GTPUniRule annotation5
Nucleotide bindingi108 – 110GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:SACOL1199
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143791 – 390Cell division protein FtsZAdd BLAST390

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi93062.SACOL1199

Structurei

3D structure databases

ProteinModelPortaliQ5HGP5
SMRiQ5HGP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HGP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEFEQGFNH LATLKVIGVG GGGNNAVNRM IDHGMNNVEF IAINTDGQAL
60 70 80 90 100
NLSKAESKIQ IGEKLTRGLG AGANPEIGKK AAEESREQIE DAIQGADMVF
110 120 130 140 150
VTSGMGGGTG TGAAPVVAKI AKEMGALTVG VVTRPFSFEG RKRQTQAAAG
160 170 180 190 200
VEAMKAAVDT LIVIPNDRLL DIVDKSTPMM EAFKEADNVL RQGVQGISDL
210 220 230 240 250
IAVSGEVNLD FADVKTIMSN QGSALMGIGV SSGENRAVEA AKKAISSPLL
260 270 280 290 300
ETSIVGAQGV LMNITGGESL SLFEAQEAAD IVQDAADEDV NMIFGTVINP
310 320 330 340 350
ELQDEIVVTV IATGFDDKPT SHGRKSGSTG FGTSVNTSSN ATSKDESFTS
360 370 380 390
NSSNAQATDS VSERTHTTKE DDIPSFIRNR EERRSRRTRR
Length:390
Mass (Da):41,037
Last modified:February 15, 2005 - v1
Checksum:iA1E97FCC5C232440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW38036.1
RefSeqiWP_000888997.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW38036; AAW38036; SACOL1199
KEGGisac:SACOL1199

Similar proteinsi

Entry informationi

Entry nameiFTSZ_STAAC
AccessioniPrimary (citable) accession number: Q5HGP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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