Reviewed, UniProtKB/Swiss-Prot Q5HGH0 (CDSA_STAAC)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	SACOL1280

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Phosphatidate cytidylyltransferase		PRO_0000090747
Regions
	Transmembrane	9 – 29	21	Potential
	Transmembrane	46 – 66	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	102 – 122	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	172 – 192	21	Potential
	Transmembrane	196 – 216	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HGH0-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 02C2727C3801C694	FASTA	260	28,964
	10 20 30 40 50 60 MKVRTLTAII ALIVFLPILL KGGLVLMIFA NILALIALKE LLNMNMIKFV SVPGLISAVG 70 80 90 100 110 120 LIIIMLPQHA GPWVQVIQLK SLIAMSFIVL SYTVLSKNRF SFMDAAFCLM SVAYVGIGFM 130 140 150 160 170 180 FFYETRSEGL HYILYAFLIV WLTDTGAYLF GKMMGKHKLW PVISPNKTIE GFIGGLFCSL 190 200 210 220 230 240 IVPLAMLYFV DFNMNVWILL GVTLILSLFG QLGDLVESGF KRHFGVKDSG RILPGHGGIL 250 260 DRFDSFMFVL PLLNILLIQS

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000046 Genomic DNA. Translation: AAW38111.1.
RefSeq	YP_186137.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HGH0.
Genome annotation databases
GeneID	3238386.
GenomeReviews	Gene locus SACOL1280 in contig CP000046_GR.
KEGG	sac:SACOL1280.
TIGR	SACOL1280.
Phylogenomic databases
HOGENOM	Q5HGH0.
OMA	SRNRFSF.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL1280-MON.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_STAAC

Accession

Primary (citable) accession number: Q5HGH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 15, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)