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Q5HG54

- TYRA_STAAC

UniProt

Q5HG54 - TYRA_STAAC

Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSAUR93062:GCEP-1376-MONOMER.
    UniPathwayiUPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:SACOL1401
    OrganismiStaphylococcus aureus (strain COL)
    Taxonomic identifieri93062 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000530: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Prephenate dehydrogenasePRO_0000282655Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93062.SACOL1401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HG54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 291290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST
    Domaini296 – 36368ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    HOGENOMiHOG000043494.
    KOiK04517.
    OMAiLQITFKN.
    OrthoDBiEOG6B8XMB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF02153. PDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HG54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE    50
    KCLNYSEAIK KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA 100
    MIQQHECNLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP 150
    RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS 200
    QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK TYILEMIRQL 250
    KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 300
    IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER 350
    GMQALSDFDC YIQ 363
    Length:363
    Mass (Da):40,395
    Last modified:February 15, 2005 - v1
    Checksum:i8F16333DC3B816C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW36649.1.
    RefSeqiYP_186253.1. NC_002951.2.

    Genome annotation databases

    EnsemblBacteriaiAAW36649; AAW36649; SACOL1401.
    GeneIDi3236275.
    KEGGisac:SACOL1401.
    PATRICi19529017. VBIStaAur112458_1362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW36649.1 .
    RefSeqi YP_186253.1. NC_002951.2.

    3D structure databases

    ProteinModelPortali Q5HG54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93062.SACOL1401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW36649 ; AAW36649 ; SACOL1401 .
    GeneIDi 3236275.
    KEGGi sac:SACOL1401.
    PATRICi 19529017. VBIStaAur112458_1362.

    Phylogenomic databases

    eggNOGi COG0287.
    HOGENOMi HOG000043494.
    KOi K04517.
    OMAi LQITFKN.
    OrthoDBi EOG6B8XMB.

    Enzyme and pathway databases

    UniPathwayi UPA00122 ; UER00961 .
    BioCyci SAUR93062:GCEP-1376-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF02153. PDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: COL.

    Entry informationi

    Entry nameiTYRA_STAAC
    AccessioniPrimary (citable) accession number: Q5HG54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3