Q5HFG5 (AROE_STAAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	SACOL1652

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136030
Regions
	Nucleotide binding	124 – 128	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HFG5 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 700864CB11686B89	FASTA	268	29,879
	10 20 30 40 50 60 MKFAVIGNPI SHSLSPVMHR ANFNSLGLDD TYEALNIPIE DFHLIKEIIS KKELEGFNIT 70 80 90 100 110 120 IPHKERIIPY LDYVDEQAIN AGAVNTVLIK DGKWIGYNTD GIGYVKGLHS VYPDLENAYI 130 140 150 160 170 180 LILGAGGASK GIAYELAKFV KPKLTVANRT MARFESWNLN INQISLADAE KYLAEFDIVI 190 200 210 220 230 240 NTTPAGMAGN NESIINLKHL SPNTLMSDIV YIPYKTPILE EAERKGNHIY NGLDMFVYQG 250 260 AESFKIWTNK DADINSMKTA VLQQLKGE

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: COL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW38268.1.
RefSeq	YP_186492.1. NC_002951.2.
3D structure databases
ProteinModelPortal	Q5HFG5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HFG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000009028; EBSTAP00000008763; EBSTAG00000009027.
GeneID	3236249.
GenomeReviews	Gene locus SACOL1652 in contig CP000046_GR.
KEGG	sac:SACOL1652.
PATRIC	19529507. VBIStaAur112458_1609.
TIGR	SACOL1652.
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000025479.
HOGENOM	HBG553408.
OMA	TLFMKKG.
PhylomeDB	Q5HFG5.
ProtClustDB	CLSK885454.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL1652-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STAAC

Accession

Primary (citable) accession number: Q5HFG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program