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Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
Gene namesi
Name:dnaE
Ordered Locus Names:SACOL1750
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001033391 – 1065DNA polymerase III subunit alphaAdd BLAST1065

Proteomic databases

PRIDEiQ5HF71

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi93062.SACOL1750

Structurei

3D structure databases

ProteinModelPortaliQ5HF71
SMRiQ5HF71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0B Bacteria
COG0587 LUCA
HOGENOMiHOG000021785
KOiK02337
OMAiKSHSTCY

Family and domain databases

InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha
IPR029460 DNAPol_HHH
IPR004365 NA-bd_OB_tRNA
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 1 hit
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF01336 tRNA_anti-codon, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HF71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAYLNIHTA YDLLNSSLKI EDAVRLAVSE NVDALAITDT NVLYGFPKFY
60 70 80 90 100
DACIANNIKP IFGMTIYVTN GLNTVETVVL AKNNDGLKDL YQLSSEIKMN
110 120 130 140 150
ALEHVSFELL KRFSNNMIII FKKVGDQHRD IVQVFETHND TYMDHLSISI
160 170 180 190 200
QGRKHVWIQN VCYQTRQDAD TISALAAIRD NTKLDLIHDQ EDFGAHFLTE
210 220 230 240 250
KEINQLDINQ EYLTQVDVIA QKCDAELKYH QSLLPQYETP NDESAKKYLW
260 270 280 290 300
RVLVTQLKKL ELNYDVYLER LKYEYKVITN MGFEDYFLIV SDLIHYAKTN
310 320 330 340 350
DVMVGPGRGS SAGSLVSYLL GITTIDPIKF NLLFERFLNP ERVTMPDIDI
360 370 380 390 400
DFEDTRRERV IQYVQEKYGE LHVSGIVTFG HLLARAVARD VGRIMGFDEV
410 420 430 440 450
TLNEISSLIP HKLGITLDEA YQIDDFKKFV HRNHRHERWF SICKKLEGLP
460 470 480 490 500
RHTSTHAAGI IINDHPLYEY APLTKGDTGL LTQWTMTEAE RIGLLKIDFL
510 520 530 540 550
GLRNLSIIHQ ILTQVKKDLG INIDIEKIPF DDQKVFELLS QGDTTGIFQL
560 570 580 590 600
ESDGVRSVLK KLKPEHFEDI VAVTSLYRPG PMEEIPTYIT RRHDPSKVQY
610 620 630 640 650
LHPHLEPILK NTYGVIIYQE QIMQIASTFA NFSYGEADIL RRAMSKKNRA
660 670 680 690 700
VLESERQHFI EGAKQNGYHE DISKQIFDLI LKFADYGFPR AHAVSYSKIA
710 720 730 740 750
YIMSFLKVHY PNYFYANILS NVIGSEKKTA QMIEEAKKQG ITILPPNINE
760 770 780 790 800
SHWFYKPSQE GIYLSIGTIK GVGYQSVKVI VDERYQNGKF KDFFDFARRI
810 820 830 840 850
PKRVKTRKLL EALILVGAFD AFGKTRSTLL QAIDQVLDGD LNIEQDGFLF
860 870 880 890 900
DILTPKQMYE DKEELPDALI SQYEKEYLGF YVSQHPVDKK FVAKQYLTIF
910 920 930 940 950
KLSNAQNYKP ILVQFDKVKQ IRTKNGQNMA FVTLNDGIET LDGVIFPNQF
960 970 980 990 1000
KKYEELLSHN DLFIVSGKFD HRKQQRQLII NEIQTLATFE EQKLAFAKQI
1010 1020 1030 1040 1050
IIRNKSQIDM FEEMIKATKE NANDVVLSFY DETIKQMTTL GYINQKDSMF
1060
NNFIQSFNPS DIRLI
Length:1,065
Mass (Da):122,964
Last modified:February 15, 2005 - v1
Checksum:i35803968458EFB54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW36853.1
RefSeqiWP_000226911.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW36853; AAW36853; SACOL1750
KEGGisac:SACOL1750

Similar proteinsi

Entry informationi

Entry nameiDPO3A_STAAC
AccessioniPrimary (citable) accession number: Q5HF71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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