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Q5HF63 (ACKA_STAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetate kinase
EC=2.7.2.1
Alternative name(s):
Acetokinase
Gene names
Name:ackA
Ordered Locus Names:SACOL1760
OrganismStaphylococcus aureus (strain COL) [Complete proteome] [HAMAP]
Taxonomic identifier93062 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020

Subcellular location

Cytoplasm By similarity HAMAP MF_00020.

Sequence similarities

Belongs to the acetokinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Acetate kinase HAMAP MF_00020
PRO_0000107610

Sequences

Sequence LengthMass (Da)Tools
Q5HF63 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: D8EB19998D452607

FASTA40044,043
        10         20         30         40         50         60 
MSKLILAINA GSSSLKFQLI RMPEEELVTK GLVERIGLKD SIFTIEVNGE KVKTVQDIKD 

        70         80         90        100        110        120 
HVEAVDIMLD AFKAHNIIND INDIDGTGHR VVHGGEKFPE SVAITDEVEK EIEELSELAP 

       130        140        150        160        170        180 
LHNPANLMGI RAFRKLLPNI PHVAIFDTAF HQTMPEKAYL YSLPYHYYKD YGIRKYGFHG 

       190        200        210        220        230        240 
TSHKFVSQRA AEMLDKPIED LRIISCHIGN GASIAAIDGG KSIDTSMGFT PLAGVTMGTR 

       250        260        270        280        290        300 
SGNIDPALIP FIMEKTGKTA EQVLEILNKE SGLLGLSGTS SDLRDLSEEA ESGKARSQMA 

       310        320        330        340        350        360 
LDVFASKIHK YIGSYAARMH GVDVIVFTAG IGENSVEIRA KVLEGLEFMG VYWDPKKNEN 

       370        380        390        400 
LLRGKEGFIN YPHSPVKVVV IPTDEESMIA RDVMTFGGLK

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000046 Genomic DNA. Translation: AAW38289.1.
RefSeqYP_186594.1. NC_002951.2.

3D structure databases

ProteinModelPortalQ5HF63.
SMRQ5HF63. Positions 5-396.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HF63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000010720; EBSTAP00000010455; EBSTAG00000010719.
GeneID3236755.
GenomeReviewsGene locus SACOL1760 in contig CP000046_GR.
KEGGsac:SACOL1760.
PATRIC19529725. VBIStaAur112458_1718.
TIGRSACOL1760.

Phylogenomic databases

eggNOGCOG0282.
GeneTreeEBGT00050000024640.
HOGENOMHBG285863.
OMALIDMTNE.
ProtClustDBPRK00180.

Enzyme and pathway databases

BioCycSAUR93062:SACOL1760-MONOMER.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
[Tree]
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
KOK00925.
PANTHERPTHR21060. Acetate_kin. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. AckA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACKA_STAAC
AccessionPrimary (citable) accession number: Q5HF63
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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