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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2049-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbW (EC:2.7.11.1)
Alternative name(s):
Anti-sigma-B factor
Sigma-B negative effector RsbW
Gene namesi
Name:rsbW
Ordered Locus Names:SACOL2055
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Serine-protein kinase RsbWPRO_0000203539Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2055.

Structurei

3D structure databases

ProteinModelPortaliQ5HED6.
SMRiQ5HED6. Positions 8-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.Curated

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HED6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSKEDFIEM RVPASAEYVS LIRLTLSGVF SRAGATYDDI EDAKIAVSEA
60 70 80 90 100
VTNAVKHAYK ENNNVGIINI YFEILEDKIK IVISDKGDSF DYETTKSKIG
110 120 130 140 150
PYDKDENIDF LREGGLGLFL IESLMDEVTV YKESGVTISM TKYIKKEQVR

NNGERVEIS
Length:159
Mass (Da):17,921
Last modified:February 15, 2005 - v1
Checksum:i57FA8EB8C1F9902B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09929 Genomic DNA. Translation: CAA71067.1.
CP000046 Genomic DNA. Translation: AAW37017.1.
RefSeqiWP_001190829.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37017; AAW37017; SACOL2055.
KEGGisac:SACOL2055.
PATRICi19530385. VBIStaAur112458_2004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09929 Genomic DNA. Translation: CAA71067.1.
CP000046 Genomic DNA. Translation: AAW37017.1.
RefSeqiWP_001190829.1. NC_002951.2.

3D structure databases

ProteinModelPortaliQ5HED6.
SMRiQ5HED6. Positions 8-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW37017; AAW37017; SACOL2055.
KEGGisac:SACOL2055.
PATRICi19530385. VBIStaAur112458_2004.

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2049-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSBW_STAAC
AccessioniPrimary (citable) accession number: Q5HED6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.