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Q5HED1

- ALR1_STAAC

UniProt

Q5HED1 - ALR1_STAAC

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Protein
Alanine racemase 1
Gene
alr1, alr, SACOL2060
Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanine By similarity
Binding sitei138 – 1381Substrate By similarity
Active sitei265 – 2651Proton acceptor; specific for L-alanine By similarity
Binding sitei312 – 3121Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2054-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 1 (EC:5.1.1.1)
Gene namesi
Name:alr1
Synonyms:alr
Ordered Locus Names:SACOL2060
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000530: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Alanine racemase 1UniRule annotation
PRO_0000114567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer Inferred.1 Publication

Protein-protein interaction databases

STRINGi93062.SACOL2060.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 148
Helixi15 – 2814
Beta strandi32 – 376
Helixi39 – 435
Helixi47 – 5610
Beta strandi61 – 666
Helixi67 – 748
Turni75 – 773
Beta strandi80 – 845
Helixi90 – 923
Helixi93 – 986
Beta strandi101 – 1055
Helixi108 – 1169
Beta strandi126 – 1327
Beta strandi139 – 1413
Helixi144 – 15411
Beta strandi160 – 1667
Beta strandi174 – 1774
Helixi178 – 19114
Beta strandi197 – 2026
Helixi204 – 2096
Helixi222 – 2254
Helixi231 – 2366
Beta strandi245 – 2506
Beta strandi253 – 2575
Beta strandi275 – 2817
Helixi284 – 2863
Helixi290 – 2923
Beta strandi296 – 2994
Beta strandi302 – 3087
Beta strandi315 – 3195
Beta strandi328 – 3325
Beta strandi336 – 3383
Helixi342 – 3487
Helixi353 – 3597
Beta strandi366 – 3705
Beta strandi373 – 3775
Helixi379 – 3813

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OO2X-ray2.37A/B1-382[»]
ProteinModelPortaliQ5HED1.
SMRiQ5HED1. Positions 2-382.

Miscellaneous databases

EvolutionaryTraceiQ5HED1.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HED1-1 [UniParc]FASTAAdd to Basket

« Hide

MSDKYYRSAY MNVDLNAVAS NFKVFSTLHP NKTVMAVVKA NAYGLGSVKV    50
ARHLMENGAT FFAVATLDEA IELRMHGITA KILVLGVLPA KDIDKAIQHR 100
VALTVPSKQW LKEAIKNISG EQEKKLWLHI KLDTGMGRLG IKDTKTYQEV 150
IEIIQQYEQL VFEGVFTHFA CADEPGDMTT EQYQRFKDMV NEAIKPEYIH 200
CQNSAGSLLM DCQFCNAIRP GISLYGYYPS EYVQQKVKVH LKPSVQLIAN 250
VVQTKTLQAG ESVSYGATYT ATDPTTIALL PIGYADGYLR IMQGSFVNVN 300
GHQCEVIGRV CMDQTIVKVP DQVKAGDSVI LIDNHRESPQ SVEVVAEKQH 350
TINYEVLCNL SRRLPRIYHD GDQRFVTNEL LK 382
Length:382
Mass (Da):42,823
Last modified:February 15, 2005 - v1
Checksum:i52B3C88E9811956D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37022.1.
RefSeqiYP_186876.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37022; AAW37022; SACOL2060.
GeneIDi3238047.
KEGGisac:SACOL2060.
PATRICi19530395. VBIStaAur112458_2009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37022.1 .
RefSeqi YP_186876.1. NC_002951.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OO2 X-ray 2.37 A/B 1-382 [» ]
ProteinModelPortali Q5HED1.
SMRi Q5HED1. Positions 2-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93062.SACOL2060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW37022 ; AAW37022 ; SACOL2060 .
GeneIDi 3238047.
KEGGi sac:SACOL2060.
PATRICi 19530395. VBIStaAur112458_2009.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SAUR93062:GCEP-2054-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5HED1.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: COL.
  2. "2.37 Angstrom resolution crystal structure of an alanine racemase (alr) from Staphylococcus aureus subsp. aureus COL."
    Center for structural genomics of infectious diseases (CSGID)
    Submitted (AUG-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiALR1_STAAC
AccessioniPrimary (citable) accession number: Q5HED1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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