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Q5HED0

- ACPS_STAAC

UniProt

Q5HED0 - ACPS_STAAC

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Protein
Holo-[acyl-carrier-protein] synthase
Gene
acpS, SACOL2061
Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Magnesium By similarity
Metal bindingi59 – 591Magnesium By similarity

GO - Molecular functioni

  1. holo-[acyl-carrier-protein] synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. macromolecule biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2055-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthase (EC:2.7.8.7)
Short name:
Holo-ACP synthase
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene namesi
Name:acpS
Ordered Locus Names:SACOL2061
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000530: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Holo-[acyl-carrier-protein] synthaseUniRule annotation
PRO_0000175700Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2061.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 1111
Helixi12 – 2110
Helixi23 – 253
Helixi26 – 294
Helixi32 – 409
Helixi44 – 6522
Helixi75 – 773
Beta strandi80 – 823
Beta strandi88 – 903
Beta strandi95 – 1039
Beta strandi105 – 11612

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DXEX-ray2.51A/B/C/D/E/F1-119[»]
4JM7X-ray1.82A/B/C1-119[»]
ProteinModelPortaliQ5HED0.
SMRiQ5HED0. Positions 1-119.

Miscellaneous databases

EvolutionaryTraceiQ5HED0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0736.
HOGENOMiHOG000014315.
KOiK00997.
OMAiIAHGVSF.
OrthoDBiEOG6384R9.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HED0-1 [UniParc]FASTAAdd to Basket

« Hide

MIHGIGVDLI EIDRIQALYS KQPKLVERIL TKNEQHKFNN FTHEQRKIEF    50
LAGRFATKEA FSKALGTGLG KHVAFNDIDC YNDELGKPKI DYEGFIVHVS 100
ISHTEHYAMS QVVLEKSAF 119
Length:119
Mass (Da):13,606
Last modified:February 15, 2005 - v1
Checksum:i0B828A811774B138
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37023.1.
RefSeqiYP_186877.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37023; AAW37023; SACOL2061.
GeneIDi3238092.
KEGGisac:SACOL2061.
PATRICi19530397. VBIStaAur112458_2010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37023.1 .
RefSeqi YP_186877.1. NC_002951.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DXE X-ray 2.51 A/B/C/D/E/F 1-119 [» ]
4JM7 X-ray 1.82 A/B/C 1-119 [» ]
ProteinModelPortali Q5HED0.
SMRi Q5HED0. Positions 1-119.
ModBasei Search...

Protein-protein interaction databases

STRINGi 93062.SACOL2061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW37023 ; AAW37023 ; SACOL2061 .
GeneIDi 3238092.
KEGGi sac:SACOL2061.
PATRICi 19530397. VBIStaAur112458_2010.

Phylogenomic databases

eggNOGi COG0736.
HOGENOMi HOG000014315.
KOi K00997.
OMAi IAHGVSF.
OrthoDBi EOG6384R9.

Enzyme and pathway databases

BioCyci SAUR93062:GCEP-2055-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5HED0.

Family and domain databases

Gene3Di 3.90.470.20. 1 hit.
HAMAPi MF_00101. AcpS.
InterProi IPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view ]
Pfami PF01648. ACPS. 1 hit.
[Graphical view ]
ProDomi PD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56214. SSF56214. 1 hit.
TIGRFAMsi TIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: COL.

Entry informationi

Entry nameiACPS_STAAC
AccessioniPrimary (citable) accession number: Q5HED0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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