Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5HED0

- ACPS_STAAC

UniProt

Q5HED0 - ACPS_STAAC

Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

    Catalytic activityi

    CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81MagnesiumUniRule annotation
    Metal bindingi59 – 591MagnesiumUniRule annotation

    GO - Molecular functioni

    1. holo-[acyl-carrier-protein] synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. macromolecule biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR93062:GCEP-2055-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
    Short name:
    Holo-ACP synthaseUniRule annotation
    Alternative name(s):
    4'-phosphopantetheinyl transferase AcpSUniRule annotation
    Gene namesi
    Name:acpSUniRule annotation
    Ordered Locus Names:SACOL2061
    OrganismiStaphylococcus aureus (strain COL)
    Taxonomic identifieri93062 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000530: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Holo-[acyl-carrier-protein] synthasePRO_0000175700Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93062.SACOL2061.

    Structurei

    Secondary structure

    119
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 1111
    Helixi12 – 2110
    Helixi23 – 253
    Helixi26 – 294
    Helixi32 – 409
    Helixi44 – 6522
    Helixi75 – 773
    Beta strandi80 – 823
    Beta strandi88 – 903
    Beta strandi95 – 1039
    Beta strandi105 – 11612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DXEX-ray2.51A/B/C/D/E/F1-119[»]
    4JM7X-ray1.82A/B/C1-119[»]
    ProteinModelPortaliQ5HED0.
    SMRiQ5HED0. Positions 1-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5HED0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0736.
    HOGENOMiHOG000014315.
    KOiK00997.
    OMAiIAHGVSF.
    OrthoDBiEOG6384R9.

    Family and domain databases

    Gene3Di3.90.470.20. 1 hit.
    HAMAPiMF_00101. AcpS.
    InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
    IPR002582. ACPS.
    IPR004568. PPantethiene-prot_Trfase_dom.
    [Graphical view]
    PfamiPF01648. ACPS. 1 hit.
    [Graphical view]
    ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56214. SSF56214. 1 hit.
    TIGRFAMsiTIGR00516. acpS. 1 hit.
    TIGR00556. pantethn_trn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5HED0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIHGIGVDLI EIDRIQALYS KQPKLVERIL TKNEQHKFNN FTHEQRKIEF    50
    LAGRFATKEA FSKALGTGLG KHVAFNDIDC YNDELGKPKI DYEGFIVHVS 100
    ISHTEHYAMS QVVLEKSAF 119
    Length:119
    Mass (Da):13,606
    Last modified:February 15, 2005 - v1
    Checksum:i0B828A811774B138
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37023.1.
    RefSeqiYP_186877.1. NC_002951.2.

    Genome annotation databases

    EnsemblBacteriaiAAW37023; AAW37023; SACOL2061.
    GeneIDi3238092.
    KEGGisac:SACOL2061.
    PATRICi19530397. VBIStaAur112458_2010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37023.1 .
    RefSeqi YP_186877.1. NC_002951.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DXE X-ray 2.51 A/B/C/D/E/F 1-119 [» ]
    4JM7 X-ray 1.82 A/B/C 1-119 [» ]
    ProteinModelPortali Q5HED0.
    SMRi Q5HED0. Positions 1-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93062.SACOL2061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW37023 ; AAW37023 ; SACOL2061 .
    GeneIDi 3238092.
    KEGGi sac:SACOL2061.
    PATRICi 19530397. VBIStaAur112458_2010.

    Phylogenomic databases

    eggNOGi COG0736.
    HOGENOMi HOG000014315.
    KOi K00997.
    OMAi IAHGVSF.
    OrthoDBi EOG6384R9.

    Enzyme and pathway databases

    BioCyci SAUR93062:GCEP-2055-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5HED0.

    Family and domain databases

    Gene3Di 3.90.470.20. 1 hit.
    HAMAPi MF_00101. AcpS.
    InterProi IPR008278. 4-PPantetheinyl_Trfase_SF.
    IPR002582. ACPS.
    IPR004568. PPantethiene-prot_Trfase_dom.
    [Graphical view ]
    Pfami PF01648. ACPS. 1 hit.
    [Graphical view ]
    ProDomi PD004282. PPantethiene-prot_Trfase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56214. SSF56214. 1 hit.
    TIGRFAMsi TIGR00516. acpS. 1 hit.
    TIGR00556. pantethn_trn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: COL.

    Entry informationi

    Entry nameiACPS_STAAC
    AccessioniPrimary (citable) accession number: Q5HED0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3