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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi59MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:SACOL2061
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001757001 – 119Holo-[acyl-carrier-protein] synthaseAdd BLAST119

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2061.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Helixi12 – 21Combined sources10
Helixi23 – 25Combined sources3
Helixi26 – 29Combined sources4
Helixi32 – 39Combined sources8
Helixi44 – 65Combined sources22
Helixi67 – 70Combined sources4
Helixi75 – 77Combined sources3
Beta strandi80 – 82Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi95 – 103Combined sources9
Beta strandi105 – 116Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DXEX-ray2.51A/B/C/D/E/F1-119[»]
4JM7X-ray1.82A/B/C1-119[»]
5CXDX-ray1.75A/B/C1-119[»]
ProteinModelPortaliQ5HED0.
SMRiQ5HED0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5HED0.

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiHGVSFQD.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HED0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHGIGVDLI EIDRIQALYS KQPKLVERIL TKNEQHKFNN FTHEQRKIEF
60 70 80 90 100
LAGRFATKEA FSKALGTGLG KHVAFNDIDC YNDELGKPKI DYEGFIVHVS
110
ISHTEHYAMS QVVLEKSAF
Length:119
Mass (Da):13,606
Last modified:February 15, 2005 - v1
Checksum:i0B828A811774B138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37023.1.
RefSeqiWP_000581200.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37023; AAW37023; SACOL2061.
GeneIDi28380346.
KEGGisac:SACOL2061.
PATRICi19530397. VBIStaAur112458_2010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW37023.1.
RefSeqiWP_000581200.1. NC_002951.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DXEX-ray2.51A/B/C/D/E/F1-119[»]
4JM7X-ray1.82A/B/C1-119[»]
5CXDX-ray1.75A/B/C1-119[»]
ProteinModelPortaliQ5HED0.
SMRiQ5HED0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW37023; AAW37023; SACOL2061.
GeneIDi28380346.
KEGGisac:SACOL2061.
PATRICi19530397. VBIStaAur112458_2010.

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiHGVSFQD.

Miscellaneous databases

EvolutionaryTraceiQ5HED0.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACPS_STAAC
AccessioniPrimary (citable) accession number: Q5HED0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.