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Protein

Formimidoylglutamase

Gene

hutG

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Manganese 1UniRule annotation1
Metal bindingi155Manganese 1UniRule annotation1
Metal bindingi155Manganese 2UniRule annotation1
Metal bindingi157Manganese 2UniRule annotation1
Metal bindingi159Manganese 1UniRule annotation1
Metal bindingi242Manganese 1UniRule annotation1
Metal bindingi242Manganese 2UniRule annotation1
Metal bindingi244Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:SACOL2327
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737661 – 311FormimidoylglutamaseAdd BLAST311

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2327

Structurei

3D structure databases

ProteinModelPortaliQ5HDM3
SMRiQ5HDM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41088SP Bacteria
COG0010 LUCA
HOGENOMiHOG000237658
KOiK01479
OMAiNFDAHLD

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01227 hutG, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HDM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKQGEPNLW TGRLDSETDP KKFRHFQTVT FEDLSKLEKS SMPSGVGILG
60 70 80 90 100
YAVDKGVALN KGRIGAKEGP DAIKQAFAGL PDLNQCETLV DYGNVYHDHE
110 120 130 140 150
ELIDTQKEFA MLAAKSIANH RQTFLLGGGH DIAYAQYLAT RKVYPTQSIG
160 170 180 190 200
VINIDAHFDT RAEQQSTSGT SFRQILEEDE NTDYLVLGIA QGGNTQSLFD
210 220 230 240 250
YAKEKKIDYV FADELLSHVS PTIKDMIERF VHEHDVIMFT ICMDVIDSAF
260 270 280 290 300
APGVSAPAVL GLYPHTVLEL AKRIIPSDKV SSVSIAEMNP TYDADNRTAK
310
LVANLVHHFL K
Length:311
Mass (Da):34,513
Last modified:February 15, 2005 - v1
Checksum:i2300211543656C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW37156.1
RefSeqiWP_000277968.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW37156; AAW37156; SACOL2327
KEGGisac:SACOL2327

Similar proteinsi

Entry informationi

Entry nameiHUTG_STAAC
AccessioniPrimary (citable) accession number: Q5HDM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health