Q5HDJ0 (MQO1_STAAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase 1
EC=1.1.5.4

Alternative name(s):
MQO 1
Malate dehydrogenase [quinone] 1

Gene names

Name:	mqo1
Ordered Locus Names:	SACOL2362

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Probable malate:quinone oxidoreductase 1 HAMAP MF_00212		PRO_0000128737

Sequences

	Sequence		Length	Mass (Da)
	Q5HDJ0 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 0771A20F2DDCA0F7	FASTA	492	54,814
	10 20 30 40 50 60 MTTQHSKTDV ILIGGGIMSA TLGTLLKELS PEKNIKVFEK LAQPGEESSN VWNNAGTGHS 70 80 90 100 110 120 ALCELNYTKE GKDGTVDCSK AIKINEQYQI SKQFWAYLVK TGQLDNPDRF IQAVPHMSFV 130 140 150 160 170 180 IGEDNVAFIK SRVATLKKSI LFEKMKLSQD EEEMKSWVPL MIEGRKSDEP IALTYDETGT 190 200 210 220 230 240 DVNFGALTAK LFDNLEQRGV GIQYKQNVLD IKKQKSGVWL VKVKDLETNE TTTYESDFVF 250 260 270 280 290 300 IGAGGASLPL LQKTGIKQSK HIGGFPVSGL FLRCTNQEVI DRHHAKVYGK AAVGAPPMSV 310 320 330 340 350 360 PHLDTRFVDG KRSLLFGPFA GFSPKFLKTG SHMDLIKSVK PNNIVTMLSA GIKEMSLTKY 370 380 390 400 410 420 LVSQLMLSND ERMDDLRVFF PNAKNEDWEV ITAGQRVQVI KDTEDSKGNL QFGTEVITSD 430 440 450 460 470 480 DGTLAALLGA SPGASTAVDI MFDVLQRCYR DEFKGWEPKI KEMVPSFGYR LTDHEDLYHK 490 INEEVTKYLQ VK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: COL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW37189.1.
RefSeq	YP_187167.1. NC_002951.2.
3D structure databases
ProteinModelPortal	Q5HDJ0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HDJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000010490; EBSTAP00000010225; EBSTAG00000010489.
GeneID	3236601.
GenomeReviews	Gene locus SACOL2362 in contig CP000046_GR.
KEGG	sac:SACOL2362.
PATRIC	19531010. VBIStaAur112458_2307.
TIGR	SACOL2362.
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000024300.
HOGENOM	HBG289663.
OMA	KKWVPLM.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL2362-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO1_STAAC

Accession

Primary (citable) accession number: Q5HDJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program