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Q5HD29 (LDHD_STAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-lactate dehydrogenase
Short name=D-LDH
EC=1.1.1.28
Alternative name(s):
D-specific D-2-hydroxyacid dehydrogenase
Gene names
Name:ldhD
Synonyms:ddh
Ordered Locus Names:SACOL2535
OrganismStaphylococcus aureus (strain COL) [Complete proteome] [HAMAP]
Taxonomic identifier93062 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-lactate + NAD+ = pyruvate + NADH.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionD-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330D-lactate dehydrogenase
PRO_0000075959

Regions

Nucleotide binding156 – 1572NAD By similarity
Nucleotide binding233 – 2353NAD By similarity
Nucleotide binding296 – 2994NAD By similarity

Sites

Active site2351 By similarity
Active site2641 By similarity
Active site2961Proton donor By similarity
Binding site2591NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HD29 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: A483404D1D240230

FASTA33036,682
        10         20         30         40         50         60 
MTKIMFFGTR DYEKEMALNW GKKNNVEVTT SKELLSSATV DQLKDYDGVT TMQFGKLEND 

        70         80         90        100        110        120 
VYPKLESYGI KQIAQRTAGF DMYDLDLAKK HNIVISNVPS YSPETIAEYS VSIALQLVRR 

       130        140        150        160        170        180 
FPDIERRVQA HDFTWQAEIM SKPVKNMTVA IIGTGRIGAA TAKIYAGFGA TITAYDAYPN 

       190        200        210        220        230        240 
KDLDFLTYKD SVKEAIKDAD IISLHVPANK ESYHLFDKAM FDHVKKGAIL VNAARGAVIN 

       250        260        270        280        290        300 
TPDLIAAVND GTLLGAAIDT YENEAAYFTN DWTNKDIDDK TLLELIEHER ILVTPHIAFF 

       310        320        330 
SDEAVQNLVE GGLNAALSVI NTGTCETRLN

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000046 Genomic DNA. Translation: AAW37312.1.
RefSeqYP_187328.1. NC_002951.2.

3D structure databases

ProteinModelPortalQ5HD29.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HD29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000010156; EBSTAP00000009891; EBSTAG00000010155.
GeneID3238242.
GenomeReviewsGene locus SACOL2535 in contig CP000046_GR.
KEGGsac:SACOL2535.
PATRIC19531334. VBIStaAur112458_2468.
TIGRSACOL2535.

Phylogenomic databases

eggNOGCOG1052.
GeneTreeEBGT00050000024534.
HOGENOMHBG731446.
OMATWGLPIR.
ProtClustDBPRK12480.

Enzyme and pathway databases

BioCycSAUR93062:SACOL2535-MONOMER.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KOK03778.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDHD_STAAC
AccessionPrimary (citable) accession number: Q5HD29
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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