Q5HD29 (LDHD_STAAC) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: D-lactate dehydrogenase Short name=D-LDH EC=1.1.1.28 Alternative name(s): D-specific D-2-hydroxyacid dehydrogenase | ||||||
| Gene names |
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| Organism | Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 93062 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 330 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (R)-lactate + NAD+ = pyruvate + NADH. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | D-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC NAD bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 330 | 330 | D-lactate dehydrogenase | PRO_0000075959 | |||||
Regions | |||||||||
| Nucleotide binding | 156 – 157 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 233 – 235 | 3 | NAD By similarity | ||||||
| Nucleotide binding | 296 – 299 | 4 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 235 | 1 | By similarity | ||||||
| Active site | 264 | 1 | By similarity | ||||||
| Active site | 296 | 1 | Proton donor By similarity | ||||||
| Binding site | 259 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. Fraser C.M.J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: COL. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000046 Genomic DNA. Translation: AAW37312.1. |
| RefSeq | YP_187328.1. NC_002951.2. |
3D structure databases | |
| ProteinModelPortal | Q5HD29. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5HD29. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTAT00000010156; EBSTAP00000009891; EBSTAG00000010155. |
| GeneID | 3238242. |
| GenomeReviews | Gene locus SACOL2535 in contig CP000046_GR. |
| KEGG | sac:SACOL2535. |
| PATRIC | 19531334. VBIStaAur112458_2468. |
| TIGR | SACOL2535. |
Phylogenomic databases | |
| eggNOG | COG1052. |
| GeneTree | EBGT00050000024534. |
| HOGENOM | HBG731446. |
| OMA | TWGLPIR. |
| ProtClustDB | PRK12480. |
Enzyme and pathway databases | |
| BioCyc | SAUR93062:SACOL2535-MONOMER. |
Family and domain databases | |
| InterPro | IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 2 hits. |
| KO | K03778. |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LDHD_STAAC | ||||||||
| Accession | Primary (citable) accession number: Q5HD29 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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