Reviewed, UniProtKB/Swiss-Prot Q5HCR3 (OTCC_STAAC)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	SACOL2656

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113009
Regions
	Region	62 – 66	5	Carbamoyl phosphate binding By similarity
	Region	276 – 279	4	Ornithine binding By similarity
Sites
	Binding site	113	1	Carbamoyl phosphate By similarity
	Binding site	140	1	Carbamoyl phosphate By similarity
	Site	37	1	Important for structural integrity By similarity
	Site	153	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HCR3-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: F87470583F496AFC	FASTA	336	37,763
	10 20 30 40 50 60 MTEIQKPYDL KGRSLLKESD FTKAEFEGLI DFAITLKEYK KNGIKHHYLS GKNIALLFEK 70 80 90 100 110 120 NSTRTRAAFT VASIDLGAHP EFLGKNDIQL GKKESVEDTA KVLGRMFDGI EFRGFSQQAV 130 140 150 160 170 180 EDLAKFSGVP VWNGLTDDWH PTQMLADFMT IKENFGYLEG INLTYVGDGR NNIAHSLMVA 190 200 210 220 230 240 GAMLGVNVRI CTPKSLNPKE AYVDIAKEKA SQYGGSVMIT DNIAEAVENT DAIYTDVWVS 250 260 270 280 290 300 MGEESEFEQR INLLKDYQVN QQMFDLTGKD STIFLHCLPA FHDTNTLYGQ EIYEKYGLAE 310 320 330 MEVTDQIFRS EHSKVFDQAE NRMHTIKAVM AATLGS

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000046 Genomic DNA. Translation: AAW38654.1.
RefSeq	YP_187444.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HCR3.
Genome annotation databases
GeneID	3237045.
GenomeReviews	Gene locus SACOL2656 in contig CP000046_GR.
KEGG	sac:SACOL2656.
TIGR	SACOL2656.
Phylogenomic databases
HOGENOM	Q5HCR3.
OMA	FRSKHSK.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL2656-MON.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_STAAC

Accession

Primary (citable) accession number: Q5HCR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)