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Protein

Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR

Gene

icaR

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Represses transcription of the icaADBC operon necessary for biofilm production.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi22 – 4120H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2670-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR
Alternative name(s):
Intercellular adhesion protein R
Gene namesi
Name:icaR
Ordered Locus Names:SACOL2688
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaRPRO_0000070597Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi93062.SACOL2688.

Structurei

Secondary structure

186
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 2020Combined sources
Helixi23 – 297Combined sources
Helixi34 – 374Combined sources
Turni38 – 403Combined sources
Helixi44 – 6926Combined sources
Helixi74 – 8714Combined sources
Helixi90 – 989Combined sources
Helixi99 – 1013Combined sources
Helixi104 – 1063Combined sources
Helixi110 – 12617Combined sources
Turni131 – 1333Combined sources
Helixi138 – 16124Combined sources
Helixi165 – 18016Combined sources
Helixi181 – 1833Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GEUX-ray1.90A/B/C/D1-186[»]
ProteinModelPortaliQ5HCN2.
SMRiQ5HCN2. Positions 1-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5HCN2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5959HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108IG5. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000280321.
OMAiRYYDAND.
OrthoDBiEOG679TB9.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDKIIDNAI TLFSEKGYDG TTLDDIAKSV NIKKASLYYH FDSKKSIYEQ
60 70 80 90 100
SVKCCFDYLN NIIMMNQNKS NYSIDALYQF LFEFIFDIEE RYIRMYVQLS
110 120 130 140 150
NTPEEFSGNI YGQIQDLNQS LSKEIAKFYD ESKIKMTKED FQNLILLFLE
160 170 180
SWYLKASFSQ KFGAVEESKS QFKDEVYSLL NIFLKK
Length:186
Mass (Da):21,987
Last modified:February 15, 2005 - v1
Checksum:iF1C76B0056C7ECAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW38685.1.
RefSeqiWP_000653261.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW38685; AAW38685; SACOL2688.
KEGGisac:SACOL2688.
PATRICi19531624. VBIStaAur112458_2613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA. Translation: AAW38685.1.
RefSeqiWP_000653261.1. NC_002951.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GEUX-ray1.90A/B/C/D1-186[»]
ProteinModelPortaliQ5HCN2.
SMRiQ5HCN2. Positions 1-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW38685; AAW38685; SACOL2688.
KEGGisac:SACOL2688.
PATRICi19531624. VBIStaAur112458_2613.

Phylogenomic databases

eggNOGiENOG4108IG5. Bacteria.
COG1309. LUCA.
HOGENOMiHOG000280321.
OMAiRYYDAND.
OrthoDBiEOG679TB9.

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2670-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5HCN2.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: COL.
  2. "Crystal structure of icaR from Staphylococcus aureus, a member of the tetracycline repressor protein family."
    Center for structural genomics of infectious diseases (CSGID)
    Submitted (MAR-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiICAR_STAAC
AccessioniPrimary (citable) accession number: Q5HCN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: March 16, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Binding to the ica operator DNA involves two IcaR dimers and is highly cooperative.By similarity
In strain COL, the gene icaC is interrupted by a natural frameshift.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.