Reviewed, UniProtKB/Swiss-Prot Q5HCM7 (LIP1_STAAC)

Names and origin

Protein names

Recommended name:
    Lipase 1
    EC=3.1.1.3
Alternative name(s):
    Glycerol ester hydrolase 1

Gene names

Name:	lip1
Ordered Locus Names:	SACOL2694

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Propeptide	35 – 290	256	By similarity		PRO_0000045178
	Chain	291 – 680	390	Lipase 1		PRO_0000045179
Sites
	Active site	408	1	Charge relay system By similarity
	Active site	639	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HCM7-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: F91CD0F8648263E7	FASTA	680	76,675
	10 20 30 40 50 60 MKSQNKYSIR KFSVGASSIL IATLLFLSGG QAQAAEKQVN MGNSQEDTVT AQSIGDQQTR 70 80 90 100 110 120 ENANYQRENG VDEQQHTENL TKNLHNDKTI SEENHRKTDD LNKDQLKDDK KSSLNNKNIQ 130 140 150 160 170 180 RDTTKNNNAN PSDVNQGLEQ AINDGKQSKV ASQQQSKEAD NSQDSNANNN LPSQSRIKEA 190 200 210 220 230 240 PSLNKLDQTS QREIVNETEI EKVQPQQNNQ ANDKITNYNF NNEQEVKPQK DEKTLSVSDL 250 260 270 280 290 300 KNNQKSPVEP TKDNDKKNGL NLLKSSAVAT LPNKGTKELT AKAKDDQTNK VAKQGQYKNQ 310 320 330 340 350 360 DPIVLVHGFN GFTDDINPSV LAHYWGGNKM NIRQDLEENG YKAYEASISA FGSNYDRAVE 370 380 390 400 410 420 LYYYIKGGRV DYGAAHAAKY GHERYGKTYE GIYKDWKPGQ KVHLVGHSMG GQTIRQLEEL 430 440 450 460 470 480 LRNGNREEIE YQKKHGGEIS PLFKGNHDNM ISSITTLGTP HNGTHASDLA GNEALVRQIV 490 500 510 520 530 540 FDIGKMFGNK NSRVDFGLAQ WGLKQKPNES YIDYVKRVKQ SNLWKSKDNG FYDLTREGAT 550 560 570 580 590 600 DLNRKTSLNP NIVYKTYTGE ATHKALNSDR QKADLNMFFP FVITGNLIGK ATEKEWREND 610 620 630 640 650 660 GLVSVISSQH PFNQAYTKAT DKIQKGIWQV TPTKHDWDHV DFVGQDSSDT VRTREELQDF 670 680 WHHLADDLVK TEKLTDTKQA

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. Translation: AAW37342.1.
RefSeq	YP_187480.1.
3D structure databases
SMR	Q5HCM7. Positions 297-677.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HCM7.
Genome annotation databases
GeneID	3238361.
GenomeReviews	Gene locus SACOL2694 in contig CP000046_GR.
KEGG	sac:SACOL2694.
TIGR	SACOL2694.
Phylogenomic databases
eggNOG	COG1075.
HOGENOM	HBG694146.
OMA	YTGESTH.
Enzyme and pathway databases
BioCyc	SAUR93062:SACOL2694-MONOMER.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. [Graphical view]
Pfam	PF04650. YSIRK_signal. 1 hit. [Graphical view]
TIGRFAMs	TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP1_STAAC

Accession

Primary (citable) accession number: Q5HCM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)