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Q5HCL9

- HISX_STAAC

UniProt

Q5HCL9 - HISX_STAAC

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Protein
Histidinol dehydrogenase
Gene
hisD, SACOL2702
Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NAD By similarity
Binding sitei180 – 1801NAD By similarity
Binding sitei203 – 2031NAD By similarity
Binding sitei226 – 2261Substrate By similarity
Metal bindingi248 – 2481Zinc By similarity
Binding sitei248 – 2481Substrate By similarity
Metal bindingi251 – 2511Zinc By similarity
Binding sitei251 – 2511Substrate By similarity
Active sitei316 – 3161Proton acceptor By similarity
Active sitei317 – 3171Proton acceptor By similarity
Binding sitei317 – 3171Substrate By similarity
Metal bindingi350 – 3501Zinc By similarity
Binding sitei350 – 3501Substrate By similarity
Binding sitei404 – 4041Substrate By similarity
Metal bindingi409 – 4091Zinc By similarity
Binding sitei409 – 4091Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSAUR93062:GCEP-2684-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SACOL2702
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000530: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Histidinol dehydrogenaseUniRule annotation
PRO_0000135849Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2702.

Structurei

3D structure databases

ProteinModelPortaliQ5HCL9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HCL9-1 [UniParc]FASTAAdd to Basket

« Hide

MPMLNAQQFL NQFSLEAPLD ESLYPIIRDI CQEVKVHGDK ALKMYNLTFD    50
HTKTDHLEIS HEQIKAAFDT LDEKTKQALQ QSYERIKAYQ ESIKQTNQQL 100
EESVECYEIY HPLESVGIYV PGGKASYPST VLMTATLAQV AGVENIVVVT 150
PPQPNGVSQE VLAACYITQV DQVFQVGGAQ SIAALTYGTE TIPKVDKIVG 200
PGNQFVAYAK KYLFGQVGID QIAGPTEIAL IIDETADLDA IVYDVFAQAE 250
HDELARTYAI SEDAQVLKDL ESRIAKALPN VDRYDIVSKS IANQHYLIHA 300
SNFDEACHVM NTIAPEHASI QTVNPQPYIE KVKYVGALFI GHYSPEVIGD 350
YVAGPSHVLP TNRTARFTNG LSVNDFLTRN TVIHLSKDTF EQIADSAQHI 400
AHVEALYNHQ QSILIRQS 418
Length:418
Mass (Da):46,406
Last modified:February 15, 2005 - v1
Checksum:i69AB84E3568981F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37350.1.
RefSeqiYP_187488.1. NC_002951.2.

Genome annotation databases

EnsemblBacteriaiAAW37350; AAW37350; SACOL2702.
GeneIDi3238670.
KEGGisac:SACOL2702.
PATRICi19531652. VBIStaAur112458_2627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000046 Genomic DNA. Translation: AAW37350.1 .
RefSeqi YP_187488.1. NC_002951.2.

3D structure databases

ProteinModelPortali Q5HCL9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 93062.SACOL2702.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW37350 ; AAW37350 ; SACOL2702 .
GeneIDi 3238670.
KEGGi sac:SACOL2702.
PATRICi 19531652. VBIStaAur112458_2627.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SAUR93062:GCEP-2684-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: COL.

Entry informationi

Entry nameiHISX_STAAC
AccessioniPrimary (citable) accession number: Q5HCL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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