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Q5HCL9

- HISX_STAAC

UniProt

Q5HCL9 - HISX_STAAC

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191NADUniRule annotation
    Binding sitei180 – 1801NADUniRule annotation
    Binding sitei203 – 2031NADUniRule annotation
    Binding sitei226 – 2261SubstrateUniRule annotation
    Metal bindingi248 – 2481ZincUniRule annotation
    Binding sitei248 – 2481SubstrateUniRule annotation
    Metal bindingi251 – 2511ZincUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Active sitei316 – 3161Proton acceptorUniRule annotation
    Active sitei317 – 3171Proton acceptorUniRule annotation
    Binding sitei317 – 3171SubstrateUniRule annotation
    Metal bindingi350 – 3501ZincUniRule annotation
    Binding sitei350 – 3501SubstrateUniRule annotation
    Binding sitei404 – 4041SubstrateUniRule annotation
    Metal bindingi409 – 4091ZincUniRule annotation
    Binding sitei409 – 4091SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSAUR93062:GCEP-2684-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:SACOL2702
    OrganismiStaphylococcus aureus (strain COL)
    Taxonomic identifieri93062 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000530: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Histidinol dehydrogenasePRO_0000135849Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93062.SACOL2702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HCL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HCL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMLNAQQFL NQFSLEAPLD ESLYPIIRDI CQEVKVHGDK ALKMYNLTFD    50
    HTKTDHLEIS HEQIKAAFDT LDEKTKQALQ QSYERIKAYQ ESIKQTNQQL 100
    EESVECYEIY HPLESVGIYV PGGKASYPST VLMTATLAQV AGVENIVVVT 150
    PPQPNGVSQE VLAACYITQV DQVFQVGGAQ SIAALTYGTE TIPKVDKIVG 200
    PGNQFVAYAK KYLFGQVGID QIAGPTEIAL IIDETADLDA IVYDVFAQAE 250
    HDELARTYAI SEDAQVLKDL ESRIAKALPN VDRYDIVSKS IANQHYLIHA 300
    SNFDEACHVM NTIAPEHASI QTVNPQPYIE KVKYVGALFI GHYSPEVIGD 350
    YVAGPSHVLP TNRTARFTNG LSVNDFLTRN TVIHLSKDTF EQIADSAQHI 400
    AHVEALYNHQ QSILIRQS 418
    Length:418
    Mass (Da):46,406
    Last modified:February 15, 2005 - v1
    Checksum:i69AB84E3568981F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37350.1.
    RefSeqiYP_187488.1. NC_002951.2.

    Genome annotation databases

    EnsemblBacteriaiAAW37350; AAW37350; SACOL2702.
    GeneIDi3238670.
    KEGGisac:SACOL2702.
    PATRICi19531652. VBIStaAur112458_2627.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000046 Genomic DNA. Translation: AAW37350.1 .
    RefSeqi YP_187488.1. NC_002951.2.

    3D structure databases

    ProteinModelPortali Q5HCL9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93062.SACOL2702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW37350 ; AAW37350 ; SACOL2702 .
    GeneIDi 3238670.
    KEGGi sac:SACOL2702.
    PATRICi 19531652. VBIStaAur112458_2627.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SAUR93062:GCEP-2684-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: COL.

    Entry informationi

    Entry nameiHISX_STAAC
    AccessioniPrimary (citable) accession number: Q5HCL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3