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Q5HCG1

- RUVC_EHRRW

UniProt

Q5HCG1 - RUVC_EHRRW

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene
ruvC, Erum0160, ERWE_CDS_00030
Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Metal bindingi70 – 701Magnesium By similarity
Metal bindingi142 – 1421Magnesium By similarity
Metal bindingi145 – 1451Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-3-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:Erum0160, ERWE_CDS_00030
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Crossover junction endodeoxyribonuclease RuvCUniRule annotationPRO_0000225143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum0160.

Structurei

3D structure databases

ProteinModelPortaliQ5HCG1.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HCG1-1 [UniParc]FASTAAdd to Basket

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MNIIGIDPSL NSTGWAILSV HDNNYNEIRL VDNGSILTSN KKTIGERLNK    50
IYSELLNILN SYKVDTASME EIFINKNPKS STLLCYARGV LLLTLNVACI 100
PLFEYSANRV KKSITGNGHA KKEQVCFMIE NILNIKCHGT YDISDAIAVA 150
ICHIYSIKAF 160
Length:160
Mass (Da):17,814
Last modified:February 15, 2005 - v1
Checksum:iB90FF4A05FA2A2AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH57723.1.
CR925678 Genomic DNA. Translation: CAI26497.1.
RefSeqiWP_011154699.1. NC_006832.1.
YP_179882.1. NC_005295.2.
YP_196879.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH57723; CAH57723; Erum0160.
CAI26497; CAI26497; ERWE_CDS_00030.
GeneIDi3232719.
3260793.
KEGGieru:Erum0160.
erw:ERWE_CDS_00030.
PATRICi20579727. VBIEhrRum92411_0003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH57723.1 .
CR925678 Genomic DNA. Translation: CAI26497.1 .
RefSeqi WP_011154699.1. NC_006832.1.
YP_179882.1. NC_005295.2.
YP_196879.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HCG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum0160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH57723 ; CAH57723 ; Erum0160 .
CAI26497 ; CAI26497 ; ERWE_CDS_00030 .
GeneIDi 3232719.
3260793.
KEGGi eru:Erum0160.
erw:ERWE_CDS_00030.
PATRICi 20579727. VBIEhrRum92411_0003.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci ERUM254945:GJ2L-3-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.

Entry informationi

Entry nameiRUVC_EHRRW
AccessioniPrimary (citable) accession number: Q5HCG1
Secondary accession number(s): Q5FCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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