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Q5HCC3 (Q5HCC3_EHRRW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide deformylase 1 HAMAP MF_00163
Short name=PDF 1 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163
Alternative name(s):
Polypeptide deformylase 1 HAMAP MF_00163
Gene names
Name:probable def1 EMBL CAH57765.1
Synonyms:def EMBL CAI26539.1, def1 HAMAP MF_00163
Ordered Locus Names:Erum0540, ERWE_CDS_00450
OrganismEhrlichia ruminantium (strain Welgevonden) [Complete proteome] [HAMAP]
Taxonomic identifier254945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. SAAS SAAS000181 HAMAP MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family. RuleBase RU003335 HAMAP MF_00163

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1491 By similarity HAMAP MF_00163
Metal binding1061Iron By similarity HAMAP MF_00163
Metal binding1481Iron By similarity HAMAP MF_00163
Metal binding1521Iron By similarity HAMAP MF_00163

Sequences

Sequence LengthMass (Da)Tools
Q5HCC3 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 196FE92642DE64CF

FASTA18120,816
        10         20         30         40         50         60 
MSTLSLVTIP DHRLSLCSEE VTEVTQEIKK LVDDMFEVMH TNNGIGLAAV QVGIHKRIFV 

        70         80         90        100        110        120 
ADVPVDYKDH ETIKTDGYKS HGGPYCMINP KIVDMSQEKV KMQEGCLSVP DCLEYVMRPK 

       130        140        150        160        170        180 
YVTMQYLDYN GNKCIIKAQG WLARCLEHEL DHLNGIVFLK YLSKFKRDLI VEKIRKRQPI 


N

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References

[1]"The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number."
Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E., Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M., Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C., Berthier D., Botha M., Joubert F. expand/collapse author list , Corton C.H., Thomson N.R., Allsopp M.T., Allsopp B.A.
Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005) [PubMed: 15637156] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden [ARC-OVI].
[2]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden [CIRAD].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR767821 Genomic DNA. Translation: CAH57765.1.
CR925678 Genomic DNA. Translation: CAI26539.1.
RefSeqYP_179920.1. NC_005295.2.
YP_196921.1. NC_006832.1.

3D structure databases

ProteinModelPortalQ5HCC3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HCC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3233487.
3261039.
GenomeReviewsGene locus Erum0540 in contig CR767821_GR.
Gene locus ERWE_CDS_00450 in contig CR925678_GR.
KEGGeru:Erum0540.
erw:ERWE_CDS_00450.
PATRIC20579821. VBIEhrRum92411_0048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHBG665227.
OMAGVLFVDY.
PhylomeDBQ5HCC3.
ProtClustDBCLSK749063.

Family and domain databases

HAMAPMF_00163. Pep_deformylase.
[Tree]
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
Gene3DG3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KOK01462.
PANTHERPTHR10458. Fmet_deformylase. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. Fmet_deformylase. 1 hit.
TIGRFAMsTIGR00079. Pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5HCC3_EHRRW
AccessionPrimary (citable) accession number: Q5HCC3
Secondary accession number(s): Q5FCI1
Entry history
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info