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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 177ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:Erum2870, ERWE_CDS_02930
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141771 – 464Chromosomal replication initiator protein DnaAAdd BLAST464

Interactioni

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_02930.

Structurei

3D structure databases

ProteinModelPortaliQ5HBP0.
SMRiQ5HBP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235660.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HBP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNDNTEVLE NYPQDGLQSN SHIIWKGIQS RLHKFYGNAI YDSWLSVLLY
60 70 80 90 100
VSTESGKVLL SAPTRFIKEW ILVHYLDQIL KYWQDEDQSI CSVDICVVSN
110 120 130 140 150
QDPNLLVDIK DRVDRGIKGN CDNVSSPLDP RFTFDNFVVG KPNELAFAAA
160 170 180 190 200
RRVAESNSPI SGSNPLFLYG GVGLGKTHLM HAIAWYIIKS CSKRKIAYLS
210 220 230 240 250
AEKFMYQYVT ALRSKDIMLF KEQFRSVDIL MVDDVQFISG KDSTQEEFFH
260 270 280 290 300
TFNALIDQNK QLVISADRSP SDLDGVEERI KSRLGWGLVA DINETTFELR
310 320 330 340 350
LGILQLKVEK MGINIPNKVL EFLAKNIKSN IRELEGALNK VVAHSSLVGC
360 370 380 390 400
SITLDTASDI LSDLLRANHK SVTLECIQKK VAEFFNIKVS DMYSTRRLRT
410 420 430 440 450
LARPRQIAMY LSKKLTQKSL PEIGKSFGGR DHATVIHAVK QIEKLMDTDS
460
KLRDDINLLN RMLR
Length:464
Mass (Da):52,675
Last modified:February 15, 2005 - v1
Checksum:iE87D303D94EC069C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58004.1.
CR925678 Genomic DNA. Translation: CAI26787.1.
RefSeqiWP_011154971.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58004; CAH58004; Erum2870.
CAI26787; CAI26787; ERWE_CDS_02930.
KEGGieru:Erum2870.
erw:ERWE_CDS_02930.
PATRICi20580376. VBIEhrRum92411_0310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58004.1.
CR925678 Genomic DNA. Translation: CAI26787.1.
RefSeqiWP_011154971.1. NC_006832.1.

3D structure databases

ProteinModelPortaliQ5HBP0.
SMRiQ5HBP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_02930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH58004; CAH58004; Erum2870.
CAI26787; CAI26787; ERWE_CDS_02930.
KEGGieru:Erum2870.
erw:ERWE_CDS_02930.
PATRICi20580376. VBIEhrRum92411_0310.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235660.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_EHRRW
AccessioniPrimary (citable) accession number: Q5HBP0
Secondary accession number(s): Q5FE86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.