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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei595ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:G1GI0-472-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Erum3010, ERWE_CDS_03070
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347551 – 830Leucine--tRNA ligaseAdd BLAST830

Proteomic databases

PRIDEiQ5HBM8

Interactioni

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_03070

Structurei

3D structure databases

ProteinModelPortaliQ5HBM8
SMRiQ5HBM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 44"HIGH" regionAdd BLAST11
Motifi592 – 596"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HBM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYNFKEVER DVQEKWDFTV NVKDVQCYVL EMFPYPSGNI HMGHLRNYTI
60 70 80 90 100
GDVIARYKRA CGLHVFHPIG WDAFGLPAEN AALSYNISPQ VWTRKNIDNM
110 120 130 140 150
RSQLKSIGLS YNWDKEFATC DAEYYKYEQE FFLDFLKYGL AYRKESLVNW
160 170 180 190 200
DPVDQTVLAN EQVIDGRGWR SGAIIEKRKL SQWFLKITDF AAELLDDLKS
210 220 230 240 250
LNQWPEKVKL MQERWIGKSE GVIIDFQIVG INEVLQVFTT SPHTLFGASF
260 270 280 290 300
IAVSFDHPIL KYVNDVQLIQ LIDNFDRKDL IDESSINTVE KFGINSGLVA
310 320 330 340 350
RHPLLDVDLP IYVANFVLMN YGTGAVFCCP AHDQRDFDFA KKYSLPIRQV
360 370 380 390 400
IFPEQNVDLE QEAYVGSGIM GCSGFLDGMT VDDAKKSMIE KLISLGICKK
410 420 430 440 450
QVYYRLHDWG ISRQRYWGCP IPIIYCKKCG IVPVDKKDLP ITLPEDIDFT
460 470 480 490 500
KSGNPLDNHP TWKYTKCPSC GADAKRETDT FDTFFESSWY FAAFCGIGKG
510 520 530 540 550
IDKDVCNKLL PVDYYIGGIE HAVLHLLYSR FFCRALTRCG YFDVKEPFSS
560 570 580 590 600
LITQGMVCHS TYLDKYGNYL FPEDGKKMIQ EGKYVTVGRA EKMSKSKKNV
610 620 630 640 650
VHLDDIIDKY GADSARLFIL SDTPPERDIE WLDENIEGVS RYLNKLWKMI
660 670 680 690 700
VDYDQLEQNF VCDNISSDTL EYRINVHKIL NDITNDLEFY RFNCAVAKFR
710 720 730 740 750
ELSNVISEMI RLSINHHVVS EAIYILIRVV EPFIPHIAEK LWQIVGGQGM
760 770 780 790 800
LCNQLWPKVD PQLLIKKNVN IVVQVNGKFI KAVSVPNDID DDTLKSIALE
810 820 830
VAQRRIGNSS VKNIYIIPGR VINIVITKSS
Length:830
Mass (Da):95,353
Last modified:February 15, 2005 - v1
Checksum:i255DC2566DEC9A19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA Translation: CAH58018.1
CR925678 Genomic DNA Translation: CAI26801.1
RefSeqiWP_011154983.1, NC_006832.1

Genome annotation databases

EnsemblBacteriaiCAH58018; CAH58018; Erum3010
CAI26801; CAI26801; ERWE_CDS_03070
GeneIDi33058451
KEGGieru:Erum3010
erw:ERWE_CDS_03070

Similar proteinsi

Entry informationi

Entry nameiSYL_EHRRW
AccessioniPrimary (citable) accession number: Q5HBM8
Secondary accession number(s): Q5FE96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 15, 2005
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome