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Q5HBM8

- SYL_EHRRW

UniProt

Q5HBM8 - SYL_EHRRW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei595 – 5951ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM254945:GJ2L-324-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Erum3010, ERWE_CDS_03070
    OrganismiEhrlichia ruminantium (strain Welgevonden)
    Taxonomic identifieri254945 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Leucine--tRNA ligasePRO_0000334755Add
    BLAST

    Proteomic databases

    PRIDEiQ5HBM8.

    Interactioni

    Protein-protein interaction databases

    STRINGi254945.Erum3010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HBM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 4411"HIGH" regionAdd
    BLAST
    Motifi592 – 5965"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HBM8-1 [UniParc]FASTAAdd to Basket

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    MHYNFKEVER DVQEKWDFTV NVKDVQCYVL EMFPYPSGNI HMGHLRNYTI    50
    GDVIARYKRA CGLHVFHPIG WDAFGLPAEN AALSYNISPQ VWTRKNIDNM 100
    RSQLKSIGLS YNWDKEFATC DAEYYKYEQE FFLDFLKYGL AYRKESLVNW 150
    DPVDQTVLAN EQVIDGRGWR SGAIIEKRKL SQWFLKITDF AAELLDDLKS 200
    LNQWPEKVKL MQERWIGKSE GVIIDFQIVG INEVLQVFTT SPHTLFGASF 250
    IAVSFDHPIL KYVNDVQLIQ LIDNFDRKDL IDESSINTVE KFGINSGLVA 300
    RHPLLDVDLP IYVANFVLMN YGTGAVFCCP AHDQRDFDFA KKYSLPIRQV 350
    IFPEQNVDLE QEAYVGSGIM GCSGFLDGMT VDDAKKSMIE KLISLGICKK 400
    QVYYRLHDWG ISRQRYWGCP IPIIYCKKCG IVPVDKKDLP ITLPEDIDFT 450
    KSGNPLDNHP TWKYTKCPSC GADAKRETDT FDTFFESSWY FAAFCGIGKG 500
    IDKDVCNKLL PVDYYIGGIE HAVLHLLYSR FFCRALTRCG YFDVKEPFSS 550
    LITQGMVCHS TYLDKYGNYL FPEDGKKMIQ EGKYVTVGRA EKMSKSKKNV 600
    VHLDDIIDKY GADSARLFIL SDTPPERDIE WLDENIEGVS RYLNKLWKMI 650
    VDYDQLEQNF VCDNISSDTL EYRINVHKIL NDITNDLEFY RFNCAVAKFR 700
    ELSNVISEMI RLSINHHVVS EAIYILIRVV EPFIPHIAEK LWQIVGGQGM 750
    LCNQLWPKVD PQLLIKKNVN IVVQVNGKFI KAVSVPNDID DDTLKSIALE 800
    VAQRRIGNSS VKNIYIIPGR VINIVITKSS 830
    Length:830
    Mass (Da):95,353
    Last modified:February 15, 2005 - v1
    Checksum:i255DC2566DEC9A19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58018.1.
    CR925678 Genomic DNA. Translation: CAI26801.1.
    RefSeqiYP_180166.1. NC_005295.2.
    YP_197183.1. NC_006832.1.

    Genome annotation databases

    EnsemblBacteriaiCAH58018; CAH58018; Erum3010.
    CAI26801; CAI26801; ERWE_CDS_03070.
    GeneIDi3233378.
    3260922.
    KEGGieru:Erum3010.
    erw:ERWE_CDS_03070.
    PATRICi20580406. VBIEhrRum92411_0325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58018.1 .
    CR925678 Genomic DNA. Translation: CAI26801.1 .
    RefSeqi YP_180166.1. NC_005295.2.
    YP_197183.1. NC_006832.1.

    3D structure databases

    ProteinModelPortali Q5HBM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 254945.Erum3010.

    Proteomic databases

    PRIDEi Q5HBM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH58018 ; CAH58018 ; Erum3010 .
    CAI26801 ; CAI26801 ; ERWE_CDS_03070 .
    GeneIDi 3233378.
    3260922.
    KEGGi eru:Erum3010.
    erw:ERWE_CDS_03070.
    PATRICi 20580406. VBIEhrRum92411_0325.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ERUM254945:GJ2L-324-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.
    2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.

    Entry informationi

    Entry nameiSYL_EHRRW
    AccessioniPrimary (citable) accession number: Q5HBM8
    Secondary accession number(s): Q5FE96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3