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Q5HBM8

- SYL_EHRRW

UniProt

Q5HBM8 - SYL_EHRRW

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Protein

Leucine--tRNA ligase

Gene
leuS, Erum3010, ERWE_CDS_03070
Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei595 – 5951ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Erum3010, ERWE_CDS_03070
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Leucine--tRNA ligaseUniRule annotationPRO_0000334755Add
BLAST

Proteomic databases

PRIDEiQ5HBM8.

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum3010.

Structurei

3D structure databases

ProteinModelPortaliQ5HBM8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionUniRule annotationAdd
BLAST
Motifi592 – 5965"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HBM8-1 [UniParc]FASTAAdd to Basket

« Hide

MHYNFKEVER DVQEKWDFTV NVKDVQCYVL EMFPYPSGNI HMGHLRNYTI    50
GDVIARYKRA CGLHVFHPIG WDAFGLPAEN AALSYNISPQ VWTRKNIDNM 100
RSQLKSIGLS YNWDKEFATC DAEYYKYEQE FFLDFLKYGL AYRKESLVNW 150
DPVDQTVLAN EQVIDGRGWR SGAIIEKRKL SQWFLKITDF AAELLDDLKS 200
LNQWPEKVKL MQERWIGKSE GVIIDFQIVG INEVLQVFTT SPHTLFGASF 250
IAVSFDHPIL KYVNDVQLIQ LIDNFDRKDL IDESSINTVE KFGINSGLVA 300
RHPLLDVDLP IYVANFVLMN YGTGAVFCCP AHDQRDFDFA KKYSLPIRQV 350
IFPEQNVDLE QEAYVGSGIM GCSGFLDGMT VDDAKKSMIE KLISLGICKK 400
QVYYRLHDWG ISRQRYWGCP IPIIYCKKCG IVPVDKKDLP ITLPEDIDFT 450
KSGNPLDNHP TWKYTKCPSC GADAKRETDT FDTFFESSWY FAAFCGIGKG 500
IDKDVCNKLL PVDYYIGGIE HAVLHLLYSR FFCRALTRCG YFDVKEPFSS 550
LITQGMVCHS TYLDKYGNYL FPEDGKKMIQ EGKYVTVGRA EKMSKSKKNV 600
VHLDDIIDKY GADSARLFIL SDTPPERDIE WLDENIEGVS RYLNKLWKMI 650
VDYDQLEQNF VCDNISSDTL EYRINVHKIL NDITNDLEFY RFNCAVAKFR 700
ELSNVISEMI RLSINHHVVS EAIYILIRVV EPFIPHIAEK LWQIVGGQGM 750
LCNQLWPKVD PQLLIKKNVN IVVQVNGKFI KAVSVPNDID DDTLKSIALE 800
VAQRRIGNSS VKNIYIIPGR VINIVITKSS 830
Length:830
Mass (Da):95,353
Last modified:February 15, 2005 - v1
Checksum:i255DC2566DEC9A19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH58018.1.
CR925678 Genomic DNA. Translation: CAI26801.1.
RefSeqiYP_180166.1. NC_005295.2.
YP_197183.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58018; CAH58018; Erum3010.
CAI26801; CAI26801; ERWE_CDS_03070.
GeneIDi3233378.
3260922.
KEGGieru:Erum3010.
erw:ERWE_CDS_03070.
PATRICi20580406. VBIEhrRum92411_0325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR767821 Genomic DNA. Translation: CAH58018.1 .
CR925678 Genomic DNA. Translation: CAI26801.1 .
RefSeqi YP_180166.1. NC_005295.2.
YP_197183.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HBM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum3010.

Proteomic databases

PRIDEi Q5HBM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58018 ; CAH58018 ; Erum3010 .
CAI26801 ; CAI26801 ; ERWE_CDS_03070 .
GeneIDi 3233378.
3260922.
KEGGi eru:Erum3010.
erw:ERWE_CDS_03070.
PATRICi 20580406. VBIEhrRum92411_0325.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ERUM254945:GJ2L-324-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.

Entry informationi

Entry nameiSYL_EHRRW
AccessioniPrimary (citable) accession number: Q5HBM8
Secondary accession number(s): Q5FE96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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