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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi494MagnesiumUniRule annotation1
Metal bindingi500MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciERUM254945:G1GI0-547-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Erum3540, ERWE_CDS_03610
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296331 – 789Polyribonucleotide nucleotidyltransferaseAdd BLAST789

Proteomic databases

PRIDEiQ5HBH6

Interactioni

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_03610

Structurei

3D structure databases

ProteinModelPortaliQ5HBH6
SMRiQ5HBH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini561 – 620KHUniRule annotationAdd BLAST60
Domaini630 – 697S1 motifUniRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HBH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNLIRKSTE WGGKTLVLES GKIARQANGA VVVTYGGTTV LSTVVAGKAK
60 70 80 90 100
EPVDFLPLTV QFVAKSYAVG KIPGGFLKRE GKPSDRETLI SRLIDRSIRP
110 120 130 140 150
LFPSGFYDEV SIVCNLLSYD TVTPPEVTAL IGATAALAIS GVPFNGMVVG
160 170 180 190 200
ARVGYLLSED KYLLNASADE MLSSSLDLFL SGNKDSVLMV ESEASELSES
210 220 230 240 250
QMLGAISFGH QNCQEVIKLI EEFREESGIL PFGFIPHDIT SLVDDIASSY
260 270 280 290 300
TESFSIAYSN IVKKERVLEL EKLRDQVLSD MLAKYEQPNG NLQCQYSSQD
310 320 330 340 350
IISALKSFER SLVRSKIIET SSRIDGRAFN GIRDIEIEID VLPKTHGSAL
360 370 380 390 400
FTRGNTQALV VTALGTPQDE QIVDDLDGDR RENFLLHYNF PPYAVGESAA
410 420 430 440 450
LRAPGRREIG HGKLAWKAIR YVLPEKSDFP YTIRVVSEIT ESDGSSSMAT
460 470 480 490 500
VCGASLALMD TGVPIKAPVA GIAMGLIKEG EKFIILSDIL GDEDHLGDMD
510 520 530 540 550
FKVAGTSSGI TALQMDMKIS GISIEVIEKS LLQAKDGRMH ILDKMNLVIQ
560 570 580 590 600
ESRECIKNHA PRIESIFINK DKIRNVIGSG GKNIREICEK TGARVEIMQD
610 620 630 640 650
GTVMIYAINN DAVEYAKNMI MDIVSEPEIG KVFDGTVIEI VKFGAFVSFL
660 670 680 690 700
GGKRGLIHIS EIKNEHINAV GSVISVNDKV KVLVIGIDRE YVQLSMRRVD
710 720 730 740 750
QETGEPIDGE LYNIRKTNSD SDDSFLSSGS VNNRHGSEKK RRGSGRSRRS
760 770 780
SGGSSYHRDD LHNNGFGNGN RSFNDNRNGN EVPRKPRFF
Length:789
Mass (Da):86,493
Last modified:February 15, 2005 - v1
Checksum:i4EED1CA32467021F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA Translation: CAH58074.1
CR925678 Genomic DNA Translation: CAI26855.1
RefSeqiWP_011155035.1, NC_006832.1

Genome annotation databases

EnsemblBacteriaiCAH58074; CAH58074; Erum3540
CAI26855; CAI26855; ERWE_CDS_03610
GeneIDi33057972
KEGGieru:Erum3540
erw:ERWE_CDS_03610

Similar proteinsi

Entry informationi

Entry nameiPNP_EHRRW
AccessioniPrimary (citable) accession number: Q5HBH6
Secondary accession number(s): Q5FEG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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