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Q5HBH6

- PNP_EHRRW

UniProt

Q5HBH6 - PNP_EHRRW

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi494 – 4941MagnesiumUniRule annotation
    Metal bindingi500 – 5001MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciERUM254945:GJ2L-381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Erum3540, ERWE_CDS_03610
    OrganismiEhrlichia ruminantium (strain Welgevonden)
    Taxonomic identifieri254945 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 789789Polyribonucleotide nucleotidyltransferasePRO_0000329633Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi254945.Erum3540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HBH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini561 – 62060KHUniRule annotationAdd
    BLAST
    Domaini630 – 69768S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HBH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNLIRKSTE WGGKTLVLES GKIARQANGA VVVTYGGTTV LSTVVAGKAK    50
    EPVDFLPLTV QFVAKSYAVG KIPGGFLKRE GKPSDRETLI SRLIDRSIRP 100
    LFPSGFYDEV SIVCNLLSYD TVTPPEVTAL IGATAALAIS GVPFNGMVVG 150
    ARVGYLLSED KYLLNASADE MLSSSLDLFL SGNKDSVLMV ESEASELSES 200
    QMLGAISFGH QNCQEVIKLI EEFREESGIL PFGFIPHDIT SLVDDIASSY 250
    TESFSIAYSN IVKKERVLEL EKLRDQVLSD MLAKYEQPNG NLQCQYSSQD 300
    IISALKSFER SLVRSKIIET SSRIDGRAFN GIRDIEIEID VLPKTHGSAL 350
    FTRGNTQALV VTALGTPQDE QIVDDLDGDR RENFLLHYNF PPYAVGESAA 400
    LRAPGRREIG HGKLAWKAIR YVLPEKSDFP YTIRVVSEIT ESDGSSSMAT 450
    VCGASLALMD TGVPIKAPVA GIAMGLIKEG EKFIILSDIL GDEDHLGDMD 500
    FKVAGTSSGI TALQMDMKIS GISIEVIEKS LLQAKDGRMH ILDKMNLVIQ 550
    ESRECIKNHA PRIESIFINK DKIRNVIGSG GKNIREICEK TGARVEIMQD 600
    GTVMIYAINN DAVEYAKNMI MDIVSEPEIG KVFDGTVIEI VKFGAFVSFL 650
    GGKRGLIHIS EIKNEHINAV GSVISVNDKV KVLVIGIDRE YVQLSMRRVD 700
    QETGEPIDGE LYNIRKTNSD SDDSFLSSGS VNNRHGSEKK RRGSGRSRRS 750
    SGGSSYHRDD LHNNGFGNGN RSFNDNRNGN EVPRKPRFF 789
    Length:789
    Mass (Da):86,493
    Last modified:February 15, 2005 - v1
    Checksum:i4EED1CA32467021F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58074.1.
    CR925678 Genomic DNA. Translation: CAI26855.1.
    RefSeqiWP_011155035.1. NC_006832.1.
    YP_180218.1. NC_005295.2.
    YP_197237.1. NC_006832.1.

    Genome annotation databases

    EnsemblBacteriaiCAH58074; CAH58074; Erum3540.
    CAI26855; CAI26855; ERWE_CDS_03610.
    GeneIDi3233445.
    3261373.
    KEGGieru:Erum3540.
    erw:ERWE_CDS_03610.
    PATRICi20580532. VBIEhrRum92411_0385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58074.1 .
    CR925678 Genomic DNA. Translation: CAI26855.1 .
    RefSeqi WP_011155035.1. NC_006832.1.
    YP_180218.1. NC_005295.2.
    YP_197237.1. NC_006832.1.

    3D structure databases

    ProteinModelPortali Q5HBH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 254945.Erum3540.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH58074 ; CAH58074 ; Erum3540 .
    CAI26855 ; CAI26855 ; ERWE_CDS_03610 .
    GeneIDi 3233445.
    3261373.
    KEGGi eru:Erum3540.
    erw:ERWE_CDS_03610.
    PATRICi 20580532. VBIEhrRum92411_0385.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci ERUM254945:GJ2L-381-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.
    2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.

    Entry informationi

    Entry nameiPNP_EHRRW
    AccessioniPrimary (citable) accession number: Q5HBH6
    Secondary accession number(s): Q5FEG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3