Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5HBF2

- ASSY_EHRRW

UniProt

Q5HBF2 - ASSY_EHRRW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei85 – 851CitrullineUniRule annotation
Binding sitei90 – 901CitrullineUniRule annotation
Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
Binding sitei117 – 1171AspartateUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei121 – 1211CitrullineUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei125 – 1251CitrullineUniRule annotation
Binding sitei176 – 1761CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei261 – 2611CitrullineUniRule annotation
Binding sitei273 – 2731CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-410-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Erum3770, ERWE_CDS_03890
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Argininosuccinate synthasePRO_0000263926Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi254945.Erum3770.

Structurei

3D structure databases

ProteinModelPortaliQ5HBF2.
SMRiQ5HBF2. Positions 3-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HBF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIVLAYSG GLDTSVILKW LQENYNCEVV VFTADIGQED DMSVIQKKAA
60 70 80 90 100
ALNVKEIFIE DLKEEFVRDF VFPMFRANTI YEGYYLLGTS IARPLIAKRQ
110 120 130 140 150
IEIAHLTGAD AVAHGATGKG NDQVRFEFGY YCCDPNIKVI APWRQWELTS
160 170 180 190 200
RHSLIEYARK NNINVPLDKV NEPPYSIDAN LLHISYEGKS LEDPYVEPDY
210 220 230 240 250
TMLSRSLTPE LASSIPEYIE ITFEQGDPIA INDISLSPAN LLHQLNKIGG
260 270 280 290 300
KHGIGIVDIV ENRYIGIKSR GIYETPGGTI LLHAHRAIES ITLDRESAHL
310 320 330 340 350
KDEIMPKYAK LIYNGYWWTT ERKMLQSLID KSQEKVNGTV RIKLYKGSVI
360 370 380 390
VVGRKSNNSL YSYNLASFDS ESQGYDHKDA EGFIKVNSLR LKKS
Length:394
Mass (Da):44,594
Last modified:February 15, 2005 - v1
Checksum:i6C2B1EF4C48D73B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925678 Genomic DNA. Translation: CAI26883.1.
CR767821 Genomic DNA. Translation: CAH58099.1.
RefSeqiWP_011155059.1. NC_006832.1.
YP_180242.1. NC_005295.2.
YP_197265.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58099; CAH58099; Erum3770.
CAI26883; CAI26883; ERWE_CDS_03890.
GeneIDi3233275.
3260971.
KEGGieru:Erum3770.
erw:ERWE_CDS_03890.
PATRICi20580593. VBIEhrRum92411_0414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925678 Genomic DNA. Translation: CAI26883.1 .
CR767821 Genomic DNA. Translation: CAH58099.1 .
RefSeqi WP_011155059.1. NC_006832.1.
YP_180242.1. NC_005295.2.
YP_197265.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HBF2.
SMRi Q5HBF2. Positions 3-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 254945.Erum3770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58099 ; CAH58099 ; Erum3770 .
CAI26883 ; CAI26883 ; ERWE_CDS_03890 .
GeneIDi 3233275.
3260971.
KEGGi eru:Erum3770.
erw:ERWE_CDS_03890.
PATRICi 20580593. VBIEhrRum92411_0414.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ERUM254945:GJ2L-410-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.

Entry informationi

Entry nameiASSY_EHRRW
AccessioniPrimary (citable) accession number: Q5HBF2
Secondary accession number(s): Q5FDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3