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Q5HBF2

- ASSY_EHRRW

UniProt

Q5HBF2 - ASSY_EHRRW

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Protein
Argininosuccinate synthase
Gene
argG, Erum3770, ERWE_CDS_03890
Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei85 – 851Citrulline By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei176 – 1761Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei261 – 2611Citrulline By similarity
Binding sitei273 – 2731Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM254945:GJ2L-410-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Erum3770, ERWE_CDS_03890
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Argininosuccinate synthaseUniRule annotation
PRO_0000263926Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi254945.Erum3770.

Structurei

3D structure databases

ProteinModelPortaliQ5HBF2.
SMRiQ5HBF2. Positions 3-393.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HBF2-1 [UniParc]FASTAAdd to Basket

« Hide

MKKIVLAYSG GLDTSVILKW LQENYNCEVV VFTADIGQED DMSVIQKKAA    50
ALNVKEIFIE DLKEEFVRDF VFPMFRANTI YEGYYLLGTS IARPLIAKRQ 100
IEIAHLTGAD AVAHGATGKG NDQVRFEFGY YCCDPNIKVI APWRQWELTS 150
RHSLIEYARK NNINVPLDKV NEPPYSIDAN LLHISYEGKS LEDPYVEPDY 200
TMLSRSLTPE LASSIPEYIE ITFEQGDPIA INDISLSPAN LLHQLNKIGG 250
KHGIGIVDIV ENRYIGIKSR GIYETPGGTI LLHAHRAIES ITLDRESAHL 300
KDEIMPKYAK LIYNGYWWTT ERKMLQSLID KSQEKVNGTV RIKLYKGSVI 350
VVGRKSNNSL YSYNLASFDS ESQGYDHKDA EGFIKVNSLR LKKS 394
Length:394
Mass (Da):44,594
Last modified:February 15, 2005 - v1
Checksum:i6C2B1EF4C48D73B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925678 Genomic DNA. Translation: CAI26883.1.
CR767821 Genomic DNA. Translation: CAH58099.1.
RefSeqiYP_180242.1. NC_005295.2.
YP_197265.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58099; CAH58099; Erum3770.
CAI26883; CAI26883; ERWE_CDS_03890.
GeneIDi3233275.
3260971.
KEGGieru:Erum3770.
erw:ERWE_CDS_03890.
PATRICi20580593. VBIEhrRum92411_0414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925678 Genomic DNA. Translation: CAI26883.1 .
CR767821 Genomic DNA. Translation: CAH58099.1 .
RefSeqi YP_180242.1. NC_005295.2.
YP_197265.1. NC_006832.1.

3D structure databases

ProteinModelPortali Q5HBF2.
SMRi Q5HBF2. Positions 3-393.
ModBasei Search...

Protein-protein interaction databases

STRINGi 254945.Erum3770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH58099 ; CAH58099 ; Erum3770 .
CAI26883 ; CAI26883 ; ERWE_CDS_03890 .
GeneIDi 3233275.
3260971.
KEGGi eru:Erum3770.
erw:ERWE_CDS_03890.
PATRICi 20580593. VBIEhrRum92411_0414.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ERUM254945:GJ2L-410-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.
  2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Welgevonden.

Entry informationi

Entry nameiASSY_EHRRW
AccessioniPrimary (citable) accession number: Q5HBF2
Secondary accession number(s): Q5FDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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