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Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei97NADUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Erum4090, ERWE_CDS_04240
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419491 – 313Malate dehydrogenaseAdd BLAST313

Proteomic databases

PRIDEiQ5HBC0

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum4090

Structurei

3D structure databases

ProteinModelPortaliQ5HBC0
SMRiQ5HBC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HBC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQSKKIALI GSGNIGGMIA YLIRLKNLGD VVLLDINDGM AKGKALDIAE
60 70 80 90 100
SSPIGKYNGE IFGTNNYADI ENADAIIVTA GITRKPGMSR DDLISTNVNI
110 120 130 140 150
IKEIATNIAK YAPNAFVIVV TNPLDVMVLA MYRYSHLPSN MIVGMAGVLD
160 170 180 190 200
SARFSYFIAK ELNVSVESVD SLVLGGHGDI MLPLIRYSSV SGVSIADLIK
210 220 230 240 250
LGMITHDKVT EIVERTRKGG EEIVSLLKTG SAYYAPAESA VLMLDSYLND
260 270 280 290 300
KKLMLPCSAY LKGEYGVHDL FVGVPIIIGK NGVEKIVELQ LTEEENSIFN
310
NSVALIQNLV ANI
Length:313
Mass (Da):33,729
Last modified:June 27, 2006 - v2
Checksum:iAE339233CEC06E2F
GO

Sequence cautioni

The sequence CAH58132 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA Translation: CAH58132.1 Different initiation.
CR925678 Genomic DNA Translation: CAI26918.1

Genome annotation databases

EnsemblBacteriaiCAH58132; CAH58132; Erum4090
CAI26918; CAI26918; ERWE_CDS_04240
KEGGieru:Erum4090
erw:ERWE_CDS_04240

Similar proteinsi

Entry informationi

Entry nameiMDH_EHRRW
AccessioniPrimary (citable) accession number: Q5HBC0
Secondary accession number(s): Q5FEX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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