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Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei97NADUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Erum4090, ERWE_CDS_04240
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419491 – 313Malate dehydrogenaseAdd BLAST313

Interactioni

Protein-protein interaction databases

STRINGi254945.Erum4090.

Structurei

3D structure databases

ProteinModelPortaliQ5HBC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HBC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQSKKIALI GSGNIGGMIA YLIRLKNLGD VVLLDINDGM AKGKALDIAE
60 70 80 90 100
SSPIGKYNGE IFGTNNYADI ENADAIIVTA GITRKPGMSR DDLISTNVNI
110 120 130 140 150
IKEIATNIAK YAPNAFVIVV TNPLDVMVLA MYRYSHLPSN MIVGMAGVLD
160 170 180 190 200
SARFSYFIAK ELNVSVESVD SLVLGGHGDI MLPLIRYSSV SGVSIADLIK
210 220 230 240 250
LGMITHDKVT EIVERTRKGG EEIVSLLKTG SAYYAPAESA VLMLDSYLND
260 270 280 290 300
KKLMLPCSAY LKGEYGVHDL FVGVPIIIGK NGVEKIVELQ LTEEENSIFN
310
NSVALIQNLV ANI
Length:313
Mass (Da):33,729
Last modified:June 27, 2006 - v2
Checksum:iAE339233CEC06E2F
GO

Sequence cautioni

The sequence CAH58132 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58132.1. Different initiation.
CR925678 Genomic DNA. Translation: CAI26918.1.
RefSeqiWP_011155091.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58132; CAH58132; Erum4090.
CAI26918; CAI26918; ERWE_CDS_04240.
KEGGieru:Erum4090.
erw:ERWE_CDS_04240.
PATRICi20580669. VBIEhrRum92411_0450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR767821 Genomic DNA. Translation: CAH58132.1. Different initiation.
CR925678 Genomic DNA. Translation: CAI26918.1.
RefSeqiWP_011155091.1. NC_006832.1.

3D structure databases

ProteinModelPortaliQ5HBC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi254945.Erum4090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH58132; CAH58132; Erum4090.
CAI26918; CAI26918; ERWE_CDS_04240.
KEGGieru:Erum4090.
erw:ERWE_CDS_04240.
PATRICi20580669. VBIEhrRum92411_0450.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_EHRRW
AccessioniPrimary (citable) accession number: Q5HBC0
Secondary accession number(s): Q5FEX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.