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Q5HB39

- SYR_EHRRW

UniProt

Q5HB39 - SYR_EHRRW

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM254945:GJ2L-540-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:Erum4910, ERWE_CDS_05130
    OrganismiEhrlichia ruminantium (strain Welgevonden)
    Taxonomic identifieri254945 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000001021: Chromosome, UP000006739: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Arginine--tRNA ligasePRO_0000242020Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi254945.Erum4910.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HB39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi132 – 14211"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247214.
    KOiK01887.
    OMAiLCNVLAK.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HB39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVACTIRRH IIEKLHVLNI DNFVVTNESI LAKLIVDYPN NPDHGDLYTN    50
    AALILSKYIK KNPMDIAKIL VDEFSSIKEI SDINVVKPGF INFNISLDVW 100
    YEIIISINRL KEKFGHVNFG NGKRVNIEFV SANPTGPMHI GHARGAIFGD 150
    VLANLLERVG YEVVREYYIN DAGAQIDVLV ESVYLRYKEV LGENIVIGSG 200
    LYPGLYLKDI GKLLYQEYDS GLLGMDYSQR RRIIRDVSLM YLMKLIKEDL 250
    ALLGIKHDIF TSESQLQKDN IVQKCVELLQ EKQLIYYGTL DQPKGTEGIN 300
    WKPRTQMLFK STDFGDDVDR ALQKADGSWT YFANDIAYHF YKISRGFQHM 350
    ILELGSDHIG YVKRLKAAVK ALSDGNATID IKLHSIVNFL DNGAQVKMSK 400
    RSGEFLTIKD VIEKVGKDVV RFIMLTRKSD VVLDFDFAKV VEQSKNNPVF 450
    YVQYAHARVH SLIRNAPKIL EIELVDFSVL SSKEEILLIK LLAKWQDIVE 500
    ISAKTAEPHR ITFYLIEIAE AFHALWGYGN KSTDMRFIVD NNINLTSARI 550
    YLAKSVGYVI ASGLTIFSIV PLTEMK 576
    Length:576
    Mass (Da):65,451
    Last modified:February 15, 2005 - v1
    Checksum:i50E4873206E02080
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58219.1.
    CR925678 Genomic DNA. Translation: CAI27007.1.
    RefSeqiYP_180355.1. NC_005295.2.
    YP_197389.1. NC_006832.1.

    Genome annotation databases

    EnsemblBacteriaiCAH58219; CAH58219; Erum4910.
    CAI27007; CAI27007; ERWE_CDS_05130.
    GeneIDi3233278.
    3260973.
    KEGGieru:Erum4910.
    erw:ERWE_CDS_05130.
    PATRICi20580870. VBIEhrRum92411_0547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR767821 Genomic DNA. Translation: CAH58219.1 .
    CR925678 Genomic DNA. Translation: CAI27007.1 .
    RefSeqi YP_180355.1. NC_005295.2.
    YP_197389.1. NC_006832.1.

    3D structure databases

    ProteinModelPortali Q5HB39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 254945.Erum4910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH58219 ; CAH58219 ; Erum4910 .
    CAI27007 ; CAI27007 ; ERWE_CDS_05130 .
    GeneIDi 3233278.
    3260973.
    KEGGi eru:Erum4910.
    erw:ERWE_CDS_05130.
    PATRICi 20580870. VBIEhrRum92411_0547.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247214.
    KOi K01887.
    OMAi LCNVLAK.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci ERUM254945:GJ2L-540-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.
    2. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Welgevonden.

    Entry informationi

    Entry nameiSYR_EHRRW
    AccessioniPrimary (citable) accession number: Q5HB39
    Secondary accession number(s): Q5FEH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3