Q5HB12 (Q5HB12_EHRRW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative Deoxyuridine 5-triphosphate nucleotidohydrolase EMBL CAI27038.1

Submitted name:
Putative deoxyuridine 5'-triphosphate nucleotidohydrolase EMBL CAH58248.1
EC=3.6.1.23 EMBL CAH58248.1

Gene names

Name:	probable dut EMBL CAH58248.1
Synonyms:	dut EMBL CAI27038.1
Ordered Locus Names:	Erum5190, ERWE_CDS_05440

Organism

Ehrlichia ruminantium (strain Welgevonden) [Complete proteome] [HAMAP]

Taxonomic identifier

254945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181 Metal-binding SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181 EMBL CAH58248.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5HB12 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: F61D6CA0A50557E5	FASTA	124	13,299
	10 20 30 40 50 60 MDLCSAVVSS IVLKPGCREC IKTGIAISVP DGYEAQIRPR SGLALKFGIT VLNTPGTIDA 70 80 90 100 110 120 DYRGEIMVIL INLGNEAYTI NYGDRIAQMV IAPVTRISWN LVEDLEANTT KRGIHGFGST GIST

References

[1]

"The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number." Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E., Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M., Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C., Berthier D., Botha M., Joubert F. , Corton C.H., Thomson N.R., Allsopp M.T., Allsopp B.A. Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005) [PubMed: 15637156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Welgevonden [ARC-OVI].

[2]

"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity." Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D. J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Welgevonden [CIRAD].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR767821 Genomic DNA. Translation: CAH58248.1. CR925678 Genomic DNA. Translation: CAI27038.1.
RefSeq	YP_180382.1. NC_005295.2. YP_197420.1. NC_006832.1.
3D structure databases
ProteinModelPortal	Q5HB12.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HB12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3233494. 3261056.
GenomeReviews	Gene locus Erum5190 in contig CR767821_GR. Gene locus ERWE_CDS_05440 in contig CR925678_GR.
KEGG	eru:Erum5190. erw:ERWE_CDS_05440.
PATRIC	20580932. VBIEhrRum92411_0577.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0756.
HOGENOM	HBG436079.
OMA	IMVILIN.
PhylomeDB	Q5HB12.
ProtClustDB	CLSK749155.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5HB12_EHRRW

Accession

Primary (citable) accession number: Q5HB12
Secondary accession number(s): Q5FEL7

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)