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Q5HAR1 (Q5HAR1_EHRRW) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase RuleBase RU000607 HAMAP MF_00323
EC=4.99.1.1 RuleBase RU000607 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323 EMBL CAH58350.1
Ordered Locus Names:Erum6180, ERWE_CDS_06490
OrganismEhrlichia ruminantium (strain Welgevonden) [Complete proteome] [HAMAP]
Taxonomic identifier254945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. SAAS SAAS001015 RuleBase RU000607 HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. SAAS SAAS001015 RuleBase RU000607 HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. SAAS SAAS001015 RuleBase RU000607 HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. RuleBase RU004185 HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
Q5HAR1 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: E6E685091BF45562

FASTA31336,302
        10         20         30         40         50         60 
MSRIAVVLFN LGGPQSLSEV KSFLFNLFYD KNIINLPNPL RFIIATLISH FRNKTATKIY 

        70         80         90        100        110        120 
QYLDGKSPIL EATKTQATLL ENVLNKHNNN QYKVFIFMRY SNPSVKETIK HVNEYNPNRI 

       130        140        150        160        170        180 
ILLPLYPHYS LTTTFSAIQH WNKYTKTENL AIPTTTICSY YHNEHYIKAQ CKLITEKYYE 

       190        200        210        220        230        240 
ACIYGLPRIL FSAHSLPLSI IQRGDPYLYQ IEHSVYLIVK FLNIPSLDYK ICYQSKVGPV 

       250        260        270        280        290        300 
KWLEPSTLSE INKAIQNNTP IVLVPISFVS ENSETLVELD IEYKSTVPEN MFFRVPTLSE 

       310 
NEGYIKCLEE MCI

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References

[1]"The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number."
Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E., Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M., Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C., Berthier D., Botha M., Joubert F. expand/collapse author list , Corton C.H., Thomson N.R., Allsopp M.T., Allsopp B.A.
Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005) [PubMed: 15637156] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden [ARC-OVI].
[2]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden [CIRAD].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR767821 Genomic DNA. Translation: CAH58350.1.
CR925678 Genomic DNA. Translation: CAI27143.1.
RefSeqYP_180483.1. NC_005295.2.
YP_197525.1. NC_006832.1.

3D structure databases

ProteinModelPortalQ5HAR1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HAR1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3233362.
3260889.
GenomeReviewsGene locus Erum6180 in contig CR767821_GR.
Gene locus ERWE_CDS_06490 in contig CR925678_GR.
KEGGeru:Erum6180.
erw:ERWE_CDS_06490.
PATRIC20581152. VBIEhrRum92411_0683.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ5HAR1.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5HAR1_EHRRW
AccessionPrimary (citable) accession number: Q5HAR1
Secondary accession number(s): Q5FD89
Entry history
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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