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Q5HAM9 (Q5HAM9_EHRRW) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420

EC=6.3.5.3 HAMAP-Rule MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420
Gene names
Name:probable purL EMBL CAH58383.1
Synonyms:purL HAMAP-Rule MF_00420 EMBL CAI27177.1
Ordered Locus Names:Erum6510 EMBL CAH58383.1, ERWE_CDS_06830 EMBL CAI27177.1
OrganismEhrlichia ruminantium (strain Welgevonden) [Complete proteome] [HAMAP] EMBL CAH58383.1
Taxonomic identifier254945 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length1010 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP-Rule MF_00420
   Cellular componentCytoplasm HAMAP-Rule MF_00420
   LigandATP-binding HAMAP-Rule MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP-Rule MF_00420 EMBL CAH58383.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5HAM9 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 5BD1D05F49D027DD

FASTA1,010112,383
        10         20         30         40         50         60 
MIIRIGIADK TLLENYRNTT LTVYTIDTQK NLDQETINKI GTLLTNPITQ RFFTFIYNNV 

        70         80         90        100        110        120 
ELNYQEVNTT NNYNLLNIFN ANWSLEKSFL PGVTDNVGNT TKCMIKEALK CDFSLDVITS 

       130        140        150        160        170        180 
QVIFSQETVP QEKDILKIYN PLIEYCKLSI RKETGFNVRF FGNKQILDLN KLYDNSRTHN 

       190        200        210        220        230        240 
TIFIIPYVRQ EDLVPQCITQ DTCVTAVNLN IQDEELMELS KYGIHGRGGL NLSLEAMKAI 

       250        260        270        280        290        300 
QAYFKKINRN PNDIELETLA QTWSEHCKHN IFSSPIDDII DGLYKHYIKR ATYEINSEIC 

       310        320        330        340        350        360 
VSTFSDNAGA IIFDDNFIIA DKVETHNSPS ALDPFGGAIT GILGVNRDII GFGKGAKPIL 

       370        380        390        400        410        420 
NAYYFCFSES EKELYRDKMC TVSVLPSETI INGVIKGVNS GGNCSGIPTG LGSVYFDDRF 

       430        440        450        460        470        480 
QSKPLVFVGC TGIIPRIIGN TPSHLKGPAD GDYIVIAGGR TGRDGIHGAT FSSNALTENN 

       490        500        510        520        530        540 
SNSTVVQIGD PITQKKLSDA IIKEARDLNL YNAITDNGAG GLSSSIGEMG NNGFKVELNK 

       550        560        570        580        590        600 
VLLKHKNMLP WEIWVSESQE RMTLAIPPSK FPIFEKIMKK HDVEISIIGT FNNTKKAVVS 

       610        620        630        640        650        660 
YNDSIIMDID INFLHNGIPK THLKTIPWSN IISSAVDTLH NKPLDTELNE MMQRMNICSK 

       670        680        690        700        710        720 
EFISTQYDHE VQGTSVIKPI QGKGRVDGEA IVIRPILSSE RGLVKSHGLG SSYGEISTYH 

       730        740        750        760        770        780 
MAACAIDTAI RNYIAIGGNF HHLALLDNFC WCDSTNPKRL WQLKNAAQAC YDYAKIFKTP 

       790        800        810        820        830        840 
FISGKDSMFN DFKGYNNKGE PINISAPPSL LISTVGIIEN IHNAITLDVK NPGDLIYILG 

       850        860        870        880        890        900 
VTYDELGRSE YQKYSGLGNN NVPQVRAKHA KKLYKLYSNA VNTNIISSAI ALNLGGLVIG 

       910        920        930        940        950        960 
LIKSLIGGEL GAKIDLSLVP THNIEDNSIK EKVILFSESQ SRILVTIAPH NKQKFETIFK 

       970        980        990       1000       1010 
DIAHANIGII SDTNTLIINN MHIINLNTLK HSYKKFSNMK IQAYANAEYI 

« Hide

References

[1]"The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number."
Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E., Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M., Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C., Berthier D., Botha M., Joubert F. expand/collapse author list , Corton C.H., Thomson N.R., Allsopp M.T., Allsopp B.A.
Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden EMBL CAH58383.1 and Welgevonden [ARC-OVI].
[2]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Welgevonden [CIRAD].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR767821 Genomic DNA. Translation: CAH58383.1.
CR925678 Genomic DNA. Translation: CAI27177.1.
RefSeqYP_180515.1. NC_005295.2.
YP_197559.1. NC_006832.1.

3D structure databases

ProteinModelPortalQ5HAM9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING254945.Erum6510.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH58383; CAH58383; Erum6510.
CAI27177; CAI27177; ERWE_CDS_06830.
GeneID3232585.
3261422.
KEGGeru:Erum6510.
erw:ERWE_CDS_06830.
PATRIC20581232. VBIEhrRum92411_0723.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000238228.
KOK01952.
OMASQERMLF.
OrthoDBEOG6FNHHR.
ProtClustDBCLSK749564.

Enzyme and pathway databases

BioCycERUM254945:GJ2L-715-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQ5HAM9_EHRRW
AccessionPrimary (citable) accession number: Q5HAM9
Secondary accession number(s): Q5FD98
Entry history
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)